Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 3/20 | 0.63 |
| ▸ | MAPT | P10636 | 7/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.58 |
| ▸ | HPGD | P15428 | 5/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | GAA | P10253 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | AIP | O00170 | 1/20 | 0.51 |
| ▸ | SGTA | O43765 | 1/20 | 0.51 |
| ▸ | TOMM70 | O94826 | 1/20 | 0.51 |
| ▸ | STIP1 | P31948 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8290727 | 0.81 | NPC1 (0.70) | MAPTALDH1A1HPGDKDM4EGAA | |
| SCHEMBL18180597 | 0.80 | L3MBTL1 (0.66) | MAPK8MAPTALDH1A1HPGDKDM4E | |
| SCHEMBL13126361 | 0.79 | MAPK8 (0.65) | MAPK8MAPTALDH1A1HPGDKDM4E | |
| SCHEMBL7669932 | 0.77 | MAPT (0.80) | MAPTALDH1A1HPGDKDM4EMEN1 | |
| SCHEMBL7003572 | 0.77 | MAPT (0.80) | MAPTALDH1A1HPGDKDM4EMEN1 | |
| SCHEMBL18177310 | 0.74 | MAPT (0.61) | MAPK8MAPTALDH1A1HPGDGAA | |
| SCHEMBL8636561 | 0.72 | MAPK8 (0.67) | MAPK8MAPTALDH1A1HPGDKDM4E | |
| SCHEMBL5245843 | 0.72 | MAPT (0.54) | MAPTALDH1A1HPGDKDM4EGAA | |
| SCHEMBL179015 | 0.72 | RAB9A (0.71) | MAPK8MAPTALDH1A1KDM4EGAA | |
| SCHEMBL1272814 | 0.71 | ALDH1A1 (0.62) | MAPK8ALDH1A1HPGDGAAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6414013-B1 | KINASE INHIBITORS; ANTICANCER AGENTS | PHARMACIA & UPJOHN S.P.A. (IT) | 2002-07-02 | — | — | US | claimed |