Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | MMP2 | P08253 | 2/20 | 0.60 |
| ▸ | MMP9 | P14780 | 2/20 | 0.60 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.60 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.60 |
| ▸ | HTR6 | P50406 | 6/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | MMP3 | P08254 | 1/20 | 0.45 |
| ▸ | MMP8 | P22894 | 1/20 | 0.45 |
| ▸ | MMP13 | P45452 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | XBP1 | P17861 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4548022 | 1.00 | LMNA (0.61) | LMNAMMP2MMP9PDK2PDK4 | |
| SCHEMBL13231955 | 0.84 | LMNA (0.48) | LMNAMMP2MMP9PDK2PDK4 | |
| SCHEMBL10826521 | 0.80 | HTR6 (0.61) | LMNAMMP2MMP9HTR6MAPT | |
| SCHEMBL13732787 | 0.80 | HTR6 (0.59) | LMNAMMP2MMP9PDK2PDK4 | |
| SCHEMBL16107692 | 0.80 | HTR6 (0.56) | LMNAMMP2MMP9PDK2PDK4 | |
| SCHEMBL3865758 | 0.78 | MMP2 (0.56) | LMNAMMP2MMP9PDK2PDK4 | |
| SCHEMBL13431417 | 0.77 | HTR6 (0.56) | LMNAMMP2MMP9HTR6MMP3 | |
| SCHEMBL2715686 | 0.76 | LMNA (1.00) | LMNAPDK2PDK4CHRM2ADORA3 | |
| SCHEMBL319934 | 0.75 | PDK2 (1.00) | LMNAPDK2PDK4CHRM2ADORA3 | |
| SCHEMBL29518706 | 0.75 | PDK2 (1.00) | LMNAPDK2PDK4CHRM2ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3405455-B1 | 2-OXINDOLE COMPOUNDS | CHEMOCENTRYX INC (US) | 2024-02-28 | — | — | EP | disclosed |
| US-10759789-B2 | 2-oxindole compounds | CHEMOCENTRYX, INC. (US) | 2020-09-01 | — | — | US | disclosed |
| US-20200123136-A1 | 2-OXINDOLE COMPOUNDS | CHEMOCENTRYX, INC. | 2020-04-23 | — | — | US | disclosed |
| US-10421748-B2 | 2-oxindole compounds | CHEMOCENTRYX, INC. (US) | 2019-09-24 | — | — | US | disclosed |
| US-20190016709-A1 | 2-OXINDOLE COMPOUNDS | CHEMOCENTRYX, INC. | 2019-01-17 | — | — | US | disclosed |
| WO-2017127409-A1 | 2-OXINDOLE COMPOUNDS | CHEMOCENTRYX, INC. (US) | 2017-07-27 | — | — | WO | disclosed |
| US-20170204087-A1 | 2-OXINDOLE COMPOUNDS | CHEMOCENTRYX, INC. | 2017-07-20 | — | — | US | disclosed |
| US-20170204087-A1 | 2-OXINDOLE COMPOUNDS | CHEMOCENTRYX, INC. | 2017-07-20 | — | — | US | disclosed |
| US-20160318856-A1 | Substituted Urea eIF2alpha Kinase Activators | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-11-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190016709-A1 | 2-OXINDOLE COMPOUNDS | CCR9, CCR1, CCRL2 | LMNA 4300/4885MMP2 2545/4885MMP9 2241/4885 |
| US-20160318856-A1 | Substituted Urea eIF2alpha Kinase Activators | EIF2AK1, EIF2A, EIF4A2 | LMNA 3011/4885MMP2 4516/4885MMP9 4871/4885 |
| US-10759789-B2 | 2-oxindole compounds | CCR9, CCR1, CCRL2 | LMNA 4300/4885MMP2 2545/4885MMP9 2241/4885 |
| US-20200123136-A1 | 2-OXINDOLE COMPOUNDS | CCR9, CCR1, CCRL2 | LMNA 4300/4885MMP2 2545/4885MMP9 2241/4885 |
| US-10421748-B2 | 2-oxindole compounds | CCR9, CCR1, CCRL2 | LMNA 4300/4885MMP2 2545/4885MMP9 2241/4885 |
| US-20170204087-A1 | 2-OXINDOLE COMPOUNDS | CCR9, CCR1, CCRL2 | LMNA 4300/4885MMP2 2545/4885MMP9 2241/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.