Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 1.00 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.73 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.73 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.73 |
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | XBP1 | P17861 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.53 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 5/20 | 0.53 |
| ▸ | MGAM | O43451 | 4/20 | 0.53 |
| ▸ | SI | P14410 | 4/20 | 0.53 |
| ▸ | MGAM2 | Q2M2H8 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2716060 | 0.89 | CHRM2 (0.93) | LMNACHRM2ADORA3KCNH2MAPT | |
| SCHEMBL22632192 | 0.89 | LMNA (0.80) | LMNACHRM2ADORA3KCNH2MAPT | |
| SCHEMBL25340217 | 0.87 | LMNA (0.76) | LMNACHRM2ADORA3KCNH2MAPT | |
| SCHEMBL2715943 | 0.86 | LMNA (0.74) | LMNACHRM2ADORA3KCNH2MAPT | |
| SCHEMBL31499330 | 0.85 | LMNA (0.73) | LMNACHRM2ADORA3KCNH2MAPT | |
| Oxyphenisatine SCHEMBL239513 | 0.85 | CHRM2 (1.00) | LMNACHRM2ADORA3KCNH2MAPT | |
| SCHEMBL9342160 | 0.85 | LMNA (0.73) | LMNACHRM2ADORA3KCNH2MAPT | |
| Oxyphenisatine SCHEMBL35387956 | 0.85 | CHRM2 (1.00) | LMNACHRM2ADORA3KCNH2MAPT | |
| SCHEMBL31499321 | 0.84 | LMNA (0.71) | LMNACHRM2ADORA3KCNH2MAPT | |
| SCHEMBL31499349 | 0.84 | LMNA (0.71) | LMNACHRM2ADORA3KCNH2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 49 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070299102-A1 | Diphenyl Ox-Indol-2-One Compounds and Their Use in the Treatment of Cancer | TOPO TARGET A/S (DK) | 2007-12-27 | — | — | US | claimed |
| EP-1734951-A2 | DIPHENYL-INDOL-2-ON COMPOUNDS AND THEIR USE IN THE TREATMENT OF CANCER | TopoTarget A/S (DK) | 2006-12-27 | — | — | EP | claimed |
| WO-2005097107-A2 | DIPHENYL - INDOL-2-ON COMPOUNDS AND THEIR USE IN THE TREATMENT OF CANCER | TOPOTARGET A/S (DK) | 2005-10-20 | — | — | WO | claimed |
| US-11773086-B2 | Fungal modulators | TRUSTEES OF BOSTON UNIVERSITY (US) | 2023-10-03 | — | — | US | disclosed |
| WO-2022198315-A1 | METHODS OF TREATING MENTAL AND/OR MOOD DISORDERS USING 2-BROMO-LSD ALONE OR IN COMBINATION WITH A MTOR INHIBITOR | BETTERLIFE PHARMA INC. (CA) | 2022-09-29 | — | — | WO | disclosed |
| US-20220064152-A1 | NOVEL FUNGAL MODULATORS | TRUSTEES OF BOSTON UNIVERSITY (US) | 2022-03-03 | — | — | US | disclosed |
| WO-2022047375-A1 | NOVEL FUNGAL MODULATORS | TRUSTEES OF BOSTON UNIVERSITY (US) | 2022-03-03 | — | — | WO | disclosed |
| EP-2945646-A1 | ESTROGEN RECEPTOR INHIBITORS | Shapiro, David J. (US) | 2015-11-25 | — | — | EP | disclosed |
| WO-2014113820-A1 | ESTROGEN RECEPTOR INHIBITORS | SHAPIRO DAVID J (US) | 2014-07-24 | — | — | WO | disclosed |
| US-8354440-B2 | 3-3-di-substituted-oxindoles as inhibitors of translation initiation | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2013-01-15 | — | — | US | disclosed |
| US-8354440-B2 | 3-3-di-substituted-oxindoles as inhibitors of translation initiation | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2013-01-15 | — | — | US | disclosed |
| US-20070099976-A1 | 3-3-DI-SUBSTITUTED-OXINDOLES AS INHIBITORS OF TRANSLATION INITIATION | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2007-05-03 | — | — | US | disclosed |
| CN-1953747-A | Diphenyl-indol-2-on compounds and their use in the treatment of cancer | TOPOTARGET AS (DK) | 2007-04-25 | — | — | CN | disclosed |
| CN-1953747-A | Diphenyl-indol-2-on compounds and their use in the treatment of cancer | TOPOTARGET AS (DK) | 2007-04-25 | — | — | CN | disclosed |
| EP-1734951-A2 | DIPHENYL-INDOL-2-ON COMPOUNDS AND THEIR USE IN THE TREATMENT OF CANCER | TopoTarget A/S (DK) | 2006-12-27 | — | — | EP | disclosed |
| EP-1734951-A2 | DIPHENYL-INDOL-2-ON COMPOUNDS AND THEIR USE IN THE TREATMENT OF CANCER | TopoTarget A/S (DK) | 2006-12-27 | — | — | EP | disclosed |
| WO-2005097107-A3 | DIPHENYL - INDOL-2-ON COMPOUNDS AND THEIR USE IN THE TREATMENT OF CANCER | BIOIMAGE AS (DK) | 2006-03-30 | — | — | WO | disclosed |
| WO-2005097107-A8 | DIPHENYL - INDOL-2-ON COMPOUNDS AND THEIR USE IN THE TREATMENT OF CANCER | BIOIMAGE AS (DK) | 2006-02-16 | — | — | WO | disclosed |
| WO-2005097107-A2 | DIPHENYL - INDOL-2-ON COMPOUNDS AND THEIR USE IN THE TREATMENT OF CANCER | TOPOTARGET A/S (DK) | 2005-10-20 | — | — | WO | disclosed |
| WO-2005097107-A2 | DIPHENYL - INDOL-2-ON COMPOUNDS AND THEIR USE IN THE TREATMENT OF CANCER | TOPOTARGET A/S (DK) | 2005-10-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11773086-B2 | Fungal modulators | ABCB11, ABCB1, ABCC1 | LMNA 4532/4885CHRM2 4720/4885ADORA3 2130/4885 |
| US-20070099976-A1 | 3-3-DI-SUBSTITUTED-OXINDOLES AS INHIBITORS OF TRANSLATION INITIATION | EIF2AK2, EIF5B, EIF4EBP1 | LMNA 1984/4885CHRM2 4865/4885ADORA3 3616/4885 |
| US-20070299102-A1 | Diphenyl Ox-Indol-2-One Compounds and Their Use in the Treatment of Cancer | MTOR, RICTOR, CDK4 | LMNA 3104/4885CHRM2 2994/4885ADORA3 3566/4885 |
| US-20220064152-A1 | NOVEL FUNGAL MODULATORS | ABCB11, ABCB1, ABCC1 | LMNA 4624/4885CHRM2 4741/4885ADORA3 2475/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.