SCHEMBL1820165

SCHEMBL1820165

NCC(=O)ON1CCCCC1

nearest known ligand 0.37

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 1/20 0.34
ALDH1A1 P00352 3/20 0.32
MAPT P10636 2/20 0.31
GAA P10253 1/20 0.31
POLB P06746 1/20 0.31
DPP7 Q9UHL4 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3897445 0.93
SCHEMBL5874140 0.81 ALDH1A1 (0.38) L3MBTL1ALDH1A1MAPTGAAPOLB
SCHEMBL2950462 0.81 ALDH1A1 (0.35) L3MBTL1ALDH1A1MAPTGAAPOLB
Water SCHEMBL9419678 0.79 ALDH1A1 (0.34) L3MBTL1ALDH1A1MAPTGAAPOLB
SCHEMBL3910470 0.79 ALDH1A1 (0.33) L3MBTL1ALDH1A1MAPTGAAPOLB
SCHEMBL3910467 0.79 ALDH1A1 (0.33) L3MBTL1ALDH1A1MAPTGAAPOLB
SCHEMBL762068 0.77 L3MBTL1 (0.35) L3MBTL1ALDH1A1MAPTGAAPOLB
SCHEMBL5874669 0.77 ATM (0.43) L3MBTL1ALDH1A1MAPTPOLB
SCHEMBL5874399 0.77 L3MBTL1 (0.39) L3MBTL1ALDH1A1MAPTPOLB
SCHEMBL5875030 0.77 ALDH1A1 (0.33) L3MBTL1ALDH1A1MAPTGAAPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 78 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7015306-B2 Labeled neurotensin derivatives BIOSYNTHEMA, INC. (US) 2006-03-21 US claimed
US-20050191240-A1 Peptide analogs of neurotensin resistant to enzymatic degradation and retain high binding affinity for neurotensin receptors; metal chelating group on one end; replacing Arg8 with Gly(PipAm) ((N-amidinopiperidinyl)glycine) for example; useful for diagnostic and therapeutic purposes ADVANCED ACCELERATOR APPLICATIONS USA, INC. 2005-09-01 US claimed
EP-1194444-A2 LABELED NEUROTENSIN DERIVATIVES WITH IMPROVED RESISTANCE TO ENZYMATIC DEGRADATION BioSynthema Inc. (US) 2002-04-10 EP claimed
WO-2000078796-A2 LABELED NEUROTENSIN DERIVATIVES WITH IMPROVED RESISTANCE TO ENZYMATIC DEGRADATION MALLINCKRODT INC. (US) 2000-12-28 WO claimed
EP-3668886-A2 TAU AGGREGATION PEPTIDE INHIBITORS Adrx, Inc. (US) 2020-06-24 EP disclosed
CN-110072883-A The relevant peptide of therapeutic MOTS-C 科巴公司 2019-07-30 CN disclosed
CN-109715185-A Water soluble and chemically stable glucagon peptides 印第安纳大学研究及科技有限公司 2019-05-03 CN disclosed
WO-2019036725-A2 TAU AGGREGATION PEPTIDE INHIBITORS ADRX, INC. (US) 2019-02-21 WO disclosed
CN-108697756-A HER2 peptide reagents and method 密歇根大学董事会 2018-10-23 CN disclosed
CN-104583233-B Show the analog of the glucagon of GIP receptor actives 印第安纳大学研究及科技有限公司 2018-10-23 CN disclosed
CN-108383902-A Insulin analog dimer 印第安纳大学研究及科技有限公司 2018-08-10 CN disclosed
CN-104995207-B β integrin-G protein α subunit binding interaction inhibitors 伊利诺伊州大学理事会 2018-08-07 CN disclosed
WO-2006039221-A2 CYCLOPROPYL PIPERIDINE GLYCINE TRANSPORTER INHIBITORS MERCK & CO., INC. (US) 2006-04-13 WO disclosed
US-7015306-B2 Labeled neurotensin derivatives BIOSYNTHEMA, INC. (US) 2006-03-21 US disclosed
US-20050191240-A1 Peptide analogs of neurotensin resistant to enzymatic degradation and retain high binding affinity for neurotensin receptors; metal chelating group on one end; replacing Arg8 with Gly(PipAm) ((N-amidinopiperidinyl)glycine) for example; useful for diagnostic and therapeutic purposes ADVANCED ACCELERATOR APPLICATIONS USA, INC. 2005-09-01 US disclosed
EP-1194444-A2 LABELED NEUROTENSIN DERIVATIVES WITH IMPROVED RESISTANCE TO ENZYMATIC DEGRADATION BioSynthema Inc. (US) 2002-04-10 EP disclosed
CN-1079792-C DP-IV-serine protease inhibitors FERRING BV (NL) 2002-02-27 CN disclosed
WO-2000078796-A2 LABELED NEUROTENSIN DERIVATIVES WITH IMPROVED RESISTANCE TO ENZYMATIC DEGRADATION MALLINCKRODT INC. (US) 2000-12-28 WO disclosed
CN-1158133-A Peptide-derived radionuclide chelators RESOLUTION PHARM INC (CA) 1997-08-27 CN disclosed
CN-1141033-A Enzyme inhibitors FERRING BV (NL) 1997-01-22 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050191240-A1 Peptide analogs of neurotensin resistant to enzymatic degradation and retain high binding affinity for neurotensin receptors; metal chelating group on one end; replacing Arg8 with Gly(PipAm) ((N-amidinopiperidinyl)glycine) for example; useful for diagnostic and therapeutic purposes ANPEP, DNPEP, NTSR1 L3MBTL1 2802/4885ALDH1A1 4467/4885MAPT 3184/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.