Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR2 | O15552 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.50 |
| ▸ | RELA | Q04206 | 1/20 | 0.50 |
| ▸ | CCR4 | P51679 | 1/20 | 0.47 |
| ▸ | ALPL | P05186 | 1/20 | 0.44 |
| ▸ | ALPI | P09923 | 1/20 | 0.44 |
| ▸ | CFTR | P13569 | 1/20 | 0.42 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2185845 | 1.00 | FFAR2 (0.51) | FFAR2GAANPC1ALDH1A1MAPT | |
| SCHEMBL262464 | 1.00 | FFAR2 (0.51) | FFAR2GAANPC1ALDH1A1MAPT | |
| SCHEMBL2185593 | 0.99 | FFAR2 (0.50) | FFAR2GAANPC1ALDH1A1MAPT | |
| SCHEMBL27818106 | 0.99 | FFAR2 (0.50) | FFAR2GAANPC1ALDH1A1MAPT | |
| SCHEMBL262345 | 0.91 | FFAR2 (0.47) | FFAR2GAANPC1ALDH1A1MAPT | |
| SCHEMBL2303876 | 0.90 | FFAR2 (0.51) | FFAR2GAANPC1ALDH1A1MAPT | |
| SCHEMBL2303870 | 0.90 | FFAR2 (0.51) | FFAR2GAANPC1ALDH1A1MAPT | |
| SCHEMBL262169 | 0.90 | FFAR2 (0.51) | FFAR2GAANPC1ALDH1A1MAPT | |
| SCHEMBL15402199 | 0.90 | FFAR2 (0.49) | FFAR2GAANPC1ALDH1A1MAPT | |
| SCHEMBL2183898 | 0.90 | FFAR2 (0.49) | FFAR2GAANPC1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 116 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4686469-A1 | CXCL8 INHIBITORS FOR USE IN THE TREATMENT OF DIABETES-ASSOCIATED COMORBIDITIES | Dompé farmaceutici SpA (IT) | 2026-02-04 | — | — | EP | claimed |
| EP-4686472-A1 | CXCL8 INHIBITORS FOR USE IN THE TREATMENT OF OCULAR GRAFT-VERSUS-HOST DISEASE | Dompé farmaceutici SpA (IT) | 2026-02-04 | — | — | EP | claimed |
| EP-4678171-A1 | SYSTEMICALLY-ADMINISTERED CXCL8 INHIBITORS FOR USE IN THE PREVENTION OR TREATMENT OF OCULAR MUCOUS MEMBRANE PEMPHIGOID AND/OR ORAL MUCOUS MEMBRANE PEMPHIGOID | Dompé farmaceutici SpA (IT) | 2026-01-14 | — | — | EP | claimed |
| EP-3518898-B1 | PREVENTION AND TREATMENT OF DIABETIC NEPHROPATHY | CHILDRENS MEDICAL CT CORP (US) | 2025-12-17 | — | — | EP | claimed |
| EP-4646193-A1 | CXCL8 INHIBITORS FOR USE IN THE TREATMENT OF OCULAR MUCOUS MEMBRANE PEMPHIGOID AND/OR ORAL MUCOUS MEMBRANE PEMPHIGOID | Dompé farmaceutici S.p.A. (IT) | 2025-11-12 | — | — | EP | claimed |
| EP-4563594-A1 | CXCL8 INHIBITORS FOR USE IN THE TREATMENT OF TUMORS WITH LOW STROMAL CAV1 LEVELS | Dompe' Farmaceutici SpA (IT) | 2025-06-04 | — | — | EP | claimed |
| US-12097172-B2 | Prevention and treatment of diabetic nephropathy | THE CHILDREN'S MEDICAL CENTER CORPORATION (US) | 2024-09-24 | — | — | US | claimed |
| WO-2024146918-A1 | CXCL8 INHIBITORS FOR USE IN THE TREATMENT OF OCULAR MUCOUS MEMBRANE PEMPHIGOID AND/OR ORAL MUCOUS MEMBRANE PEMPHIGOID | DOMPE' FARMACEUTICI SPA (IT) | 2024-07-11 | — | — | WO | claimed |
| EP-4397305-A1 | CXCL8 INHIBITORS FOR USE IN THE TREATMENT OF OCULAR MUCOUS MEMBRANE PEMPHIGOID AND/OR ORAL MUCOUS MEMBRANE PEMPHIGOID | Dompe' Farmaceutici S.P.A. (IT) | 2024-07-10 | — | — | EP | claimed |
| US-20240156757-A1 | CXCL8 INHIBITOR AND PHARMACEUTICAL COMPOSITION THEREOF FOR USE IN THE TREATMENT OF SEIZURES | DOMPE' FARMACEUTICI SPA (IT) | 2024-05-16 | — | — | US | claimed |
| US-20190224148-A1 | PREVENTION AND TREATMENT OF DIABETIC NEPHROPATHY | THE CHILDREN'S MEDICAL CENTER CORPORATION (US) | 2019-07-25 | — | — | US | claimed |
| CN-109937037-A | For treating the IL-8 inhibitor of certain urinary disorders | 东佩制药股份公司 | 2019-06-25 | — | — | CN | claimed |
| CN-107921105-A | 8 inhibitor of IL is used for the purposes for treating some urinary disorders | 东佩制药股份公司 | 2018-04-17 | — | — | CN | claimed |
| EP-2346841-B1 | 2-ARYL-PROPIONIC ACIDS AND DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | DOMPÉ S P A (IT) | 2015-01-14 | — | — | EP | claimed |
| US-8624036-B2 | 2-aryl-propionic acids and derivatives and pharmaceutical compositions containing them | DOMPE S.P.A. (IT) | 2014-01-07 | — | — | US | claimed |
| US-20110207785-A1 | 2-Aryl-Propionic Acids and Derivatives and Pharmaceutical Compositions Containing Them | DOMPE S.P.A. (IT) | 2011-08-25 | — | — | US | claimed |
| CN-102159558-A | 2-arylpropionic acids and derivatives thereof and pharmaceutical compositions containing said compounds | DOMPE SPA | 2011-08-17 | — | — | CN | claimed |
| EP-2346841-A2 | 2-ARYL-PROPIONIC ACIDS AND DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Dompe S.p.A. (IT) | 2011-07-27 | — | — | EP | claimed |
| WO-2010031835-A2 | 2-ARYL-PROPIONIC ACIDS AND DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | DOMPE' S.P.A. (IT) | 2010-03-25 | — | — | WO | claimed |
| EP-2166006-A1 | 2-aryl-propionic acids and derivatives and pharmaceutical compositions containing them | Dompe' S.P.A. (IT) | 2010-03-24 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110207785-A1 | 2-Aryl-Propionic Acids and Derivatives and Pharmaceutical Compositions Containing Them | CXCR3, F2RL1, FPR2 | FFAR2 194/4885GAA 2803/4885NPC1 1922/4885 |
| US-20240156757-A1 | CXCL8 INHIBITOR AND PHARMACEUTICAL COMPOSITION THEREOF FOR USE IN THE TREATMENT OF SEIZURES | CXCL8, CCR8, CXCL10 | FFAR2 1278/4885GAA 4014/4885NPC1 3240/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.