Sugi Predict

Sugi Predict / Compounds / SCHEMBL1820967

SCHEMBL1820967

SCHEMBL1820967

Cc1c[nH]c2c(B3OC(C)(C)C(C)(C)O3)cccc12

nearest known ligand 0.37

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ ATM Q13315 1/20 0.37
▸ NR3C1 P04150 5/20 0.36
▸ PGR P06401 4/20 0.36
▸ JAK2 O60674 3/20 0.36
▸ BTK Q06187 3/20 0.36
▸ REN P00797 2/20 0.36
▸ TRIM24 O15164 1/20 0.34
▸ TRIM33 Q9UPN9 1/20 0.34
▸ LPL P06858 2/20 0.33
▸ LIPG Q9Y5X9 2/20 0.33
▸ BRPF1 P55201 1/20 0.33
▸ HTR2A P28223 1/20 0.33
▸ MAPT P10636 1/20 0.32
▸ SMN1; SMN2 Q16637 1/20 0.32
▸ NPSR1 Q6W5P4 1/20 0.32
▸ NR3C2 P08235 3/20 0.32
▸ AR P10275 3/20 0.32
▸ NR4A2 P43354 1/20 0.31
▸ SOS2 Q07890 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29821368 1.00 ATM (0.37) ATMNR3C1PGRJAK2BTK
SCHEMBL31481819 0.83 JAK2 (0.40) JAK2BTKLPLLIPG
SCHEMBL4030052 0.83 JAK2 (0.35) NR3C1PGRJAK2BTKLPL
SCHEMBL15617056 0.80 LPL (0.43) NR3C1PGRJAK2BTKLPL
SCHEMBL29968120 0.79 SLC6A4 (0.42) ATMJAK2BTK
SCHEMBL30752373 0.79 JAK2 (0.33) NR3C1PGRJAK2BTKNR3C2
SCHEMBL30752367 0.79 JAK2 (0.33) NR3C1PGRJAK2BTKNR3C2
SCHEMBL21624164 0.79 SLC6A4 (0.42) ATMJAK2BTK
SCHEMBL21624110 0.76 GPR84 (0.36) JAK2BTKHTR2AMAPTSMN1; SMN2
SCHEMBL21624201 0.76 SLC6A4 (0.38) ATMJAK2BTK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4090661-B1 QUINOXALINE DERIVATIVES AS MODULATORS OF THE GLUCOCORTICOID RECEPTOR GRUENENTHAL GMBH (DE) 2025-03-12 — — EP disclosed
US-12110293-B2 Substituted triazolo quinoxaline derivatives Grünenthal GmbH (DE) 2024-10-08 — — US disclosed
US-11981677-B2 Further substituted triazolo quinoxaline derivatives Grünenthal GmbH (DE) 2024-05-14 — — US disclosed
EP-4090660-B1 QUINOXALINE DERIVATIVES GRUENENTHAL GMBH (DE) 2024-01-31 — — EP disclosed
EP-3823970-B1 FURTHER SUBSTITUTED TRIAZOLO QUINOXALINE DERIVATIVES GRUENENTHAL GMBH (DE) 2024-01-03 — — EP disclosed
US-20220396578-A1 QUINOXALINE DERIVATIVES GRUENENTHAL GMBH (DE) 2022-12-15 — — US disclosed
US-20220396578-A1 QUINOXALINE DERIVATIVES GRUENENTHAL GMBH (DE) 2022-12-15 — — US disclosed
US-20220372041-A1 QUINOXALINE DERIVATIVES GRUENENTHAL GMBH (DE) 2022-11-24 — — US disclosed
EP-3823971-B1 SUBSTITUTED TRIAZOLO QUINOXALINE DERIVATIVES GRUENENTHAL GMBH (DE) 2022-07-27 — — EP disclosed
WO-2021144440-A1 QUINOXALINE DERIVATIVES AS MODULATORS OF THE GLUCOCORTICOID RECEPTOR Grünenthal GmbH (DE) 2021-07-22 — — WO disclosed
WO-2020016453-A1 SUBSTITUTED TRIAZOLO QUINOXALINE DERIVATIVES Grünenthal GmbH (DE) 2020-01-23 — — WO disclosed
WO-2020016452-A1 FURTHER SUBSTITUTED TRIAZOLO QUINOXALINE DERIVATIVES Grünenthal GmbH (DE) 2020-01-23 — — WO disclosed
US-10392395-B2 Nitrogen-containing aromatic compounds and metal complexes SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2019-08-27 — — US disclosed
US-10392395-B2 Nitrogen-containing aromatic compounds and metal complexes SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2019-08-27 — — US disclosed
EP-2493890-B1 NITROGEN-CONTAINING AROMATIC COMPOUNDS AND METAL COMPLEXES SUMITOMO CHEMICAL CO (JP) 2018-03-21 — — EP disclosed
US-20120270141-A1 NITROGEN-CONTAINING AROMATIC COMPOUNDS AND METAL COMPLEXES MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V. (DE) 2012-10-25 — — US disclosed
EP-2493890-A1 NITROGEN-CONTAINING AROMATIC COMPOUNDS AND METAL COMPLEXES Sumitomo Chemical Company, Limited (JP) 2012-09-05 — — EP disclosed
WO-2011052805-A1 NITROGEN-CONTAINING AROMATIC COMPOUNDS AND METAL COMPLEXES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-05-05 — — WO disclosed
WO-2011052805-A1 NITROGEN-CONTAINING AROMATIC COMPOUNDS AND METAL COMPLEXES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-05-05 — — WO disclosed
WO-2009103007-A2 STEROID HORMONE RECEPTOR MODULATOR COMPOUNDS AND METHODS LIGAND PHARMACEUTICALS INCORPORATED (US) 2009-08-20 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220396578-A1 QUINOXALINE DERIVATIVES NR3C1, NR3C2, GRK5 ATM 3764/4885NR3C1 1/4885PGR 631/4885
US-11981677-B2 Further substituted triazolo quinoxaline derivatives NR3C1, GRK5, NR3C2 ATM 2566/4885NR3C1 1/4885PGR 345/4885
US-20120270141-A1 NITROGEN-CONTAINING AROMATIC COMPOUNDS AND METAL COMPLEXES TYR, MT-CO2, SOD1 ATM 2255/4885NR3C1 2246/4885PGR 2303/4885
US-10392395-B2 Nitrogen-containing aromatic compounds and metal complexes TYR, MT-CO2, SOD1 ATM 2255/4885NR3C1 2246/4885PGR 2303/4885
US-20220372041-A1 QUINOXALINE DERIVATIVES NR3C1, NR3C2, GRK5 ATM 3764/4885NR3C1 1/4885PGR 631/4885
US-12110293-B2 Substituted triazolo quinoxaline derivatives NR3C1, NR3C2, GRK5 ATM 2721/4885NR3C1 1/4885PGR 350/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.