Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Adenosine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 known ✓ | P0DMS8 | 4/20 | 1.00 |
| ▸ | ADORA2A known ✓ | P29274 | 1/20 | 1.00 |
| ▸ | ADORA2B known ✓ | P29275 | 1/20 | 1.00 |
| ▸ | ADORA1 known ✓ | P30542 | 1/20 | 1.00 |
| ▸ | DPP4 | P27487 | 1/20 | 1.00 |
| ▸ | MEN1 | O00255 | 1/20 | 1.00 |
| ▸ | SLC28A1 | O00337 | 1/20 | 1.00 |
| ▸ | MAP3K7 | O43318 | 1/20 | 1.00 |
| ▸ | SLC28A2 | O43868 | 1/20 | 1.00 |
| ▸ | GAPDH | P04406 | 1/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 1/20 | 1.00 |
| ▸ | STAT6 | P42226 | 1/20 | 1.00 |
| ▸ | PI4KA | P42356 | 1/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 1/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 1.00 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 1.00 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 1.00 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 1.00 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 1.00 |
| ▸ | SLC28A3 | Q9HAS3 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Adenosine SCHEMBL12352425 | 1.00 | ADORA3 (1.00) | ADORA3DPP4MEN1SLC28A1MAP3K7 | |
| Adenosine SCHEMBL1821276 | 1.00 | ADORA3 (1.00) | ADORA3DPP4MEN1SLC28A1MAP3K7 | |
| Adenosine SCHEMBL4522263 | 1.00 | ADORA3 (1.00) | ADORA3DPP4MEN1SLC28A1MAP3K7 | |
| Adenosine SCHEMBL13362239 | 1.00 | ADORA3 (1.00) | ADORA3DPP4MEN1SLC28A1MAP3K7 | |
| Adenosine SCHEMBL24538665 | 1.00 | ADORA3 (1.00) | ADORA3DPP4MEN1SLC28A1MAP3K7 | |
| Adenosine SCHEMBL23804425 | 1.00 | ADORA3 (1.00) | ADORA3DPP4MEN1SLC28A1MAP3K7 | |
| Adenosine SCHEMBL406207 | 1.00 | ADORA3 (1.00) | ADORA3DPP4MEN1SLC28A1MAP3K7 | |
| Adenosine SCHEMBL23420216 | 1.00 | ADORA3 (1.00) | ADORA3DPP4MEN1SLC28A1MAP3K7 | |
| Adenosine SCHEMBL2403819 | 1.00 | ADORA3 (1.00) | ADORA3DPP4MEN1SLC28A1MAP3K7 | |
| Adenosine SCHEMBL19107495 | 1.00 | ADORA3 (1.00) | ADORA3DPP4MEN1SLC28A1MAP3K7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 49 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10321684-B2 | Use of 9-beta-D-adenosine to increase crop production | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2019-06-18 | — | — | US | claimed |
| US-10292393-B2 | Mitigation of alternate bearing | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2019-05-21 | — | — | US | claimed |
| EP-2519106-B1 | MITIGATION OF ALTERNATE BEARING WITH 9-BETA-D-ADENOSINE | UNIV CALIFORNIA (US) | 2018-07-11 | — | — | EP | claimed |
| US-20170325456-A1 | USE OF 9-BETA-D-ADENOSINE TO INCREASE CROP PRODUCTION | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-11-16 | — | — | US | claimed |
| EP-2519105-B1 | USE OF A NATURAL METABOLITE TO INCREASE CROP PRODUCTION | UNIV CALIFORNIA (US) | 2017-05-03 | — | — | EP | claimed |
| US-20160088842-A1 | USE OF A NATURAL METABOLITE TO INCREASE CROP PRODUCTION | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2016-03-31 | — | — | US | claimed |
| US-20160021885-A1 | MITIGATION OF ALTERNATE BEARING | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2016-01-28 | — | — | US | claimed |
| CN-102762103-B | Use of natural metabolites for increasing crop production | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2015-09-16 | — | — | CN | claimed |
| US-20150141250-A1 | USE OF A NATURAL METABOLITE TO INCREASE CROP PRODUCTION | UNIV CALIFORNIA (US) | 2015-05-21 | — | — | US | claimed |
| CN-102869260-B | Mitigation of alternate bearing | UNIV CALIFORNIA | 2014-03-26 | — | — | CN | claimed |
| US-20130203596-A1 | MITIGATION OF ALTERNATE BEARING | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2013-08-08 | — | — | US | claimed |
| US-20130102465-A1 | USE OF A NATURAL METABOLITE TO INCREASE CROP PRODUCTION | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2013-04-25 | — | — | US | claimed |
| CN-102869260-A | Mitigation of alternate bearing | UNIV CALIFORNIA | 2013-01-09 | — | — | CN | claimed |
| EP-2519106-A2 | MITIGATION OF ALTERNATE BEARING | The Regents of the University of California (US) | 2012-11-07 | — | — | EP | claimed |
| CN-102762103-A | Use of natural metabolites for increasing crop production | UNIV CALIFORNIA | 2012-10-31 | — | — | CN | claimed |
| WO-2011090727-A2 | MITIGATION OF ALTERNATE BEARING | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-07-28 | — | — | WO | claimed |
| US-20230212213-A1 | A PLATFORM FOR SCREENING NAD+ BINDING PROTEINS IN A CELLULAR CONTEXT | UNIV OREGON HEALTH & SCIENCE (US) | 2023-07-06 | — | — | US | disclosed |
| WO-2021262548-A1 | A PLATFORM FOR SCREENING NAD+ BINDING PROTEINS IN A CELLULAR CONTEXT | OREGON HEALTH & SCIENCE UNIVERSITY (US) | 2021-12-30 | — | — | WO | disclosed |
| US-20080188440-A1 | Beta-L-2'-Deoxy-Nucleosides for the Treatment of Hepatitis B | IDENIX PHARMACEUTICALS, INC. (US) | 2008-08-07 | — | — | US | disclosed |
| US-20080064655-A1 | Beta-L-2'-Deoxy-Nucleosides for the Treatment of Hepatitis B | INDENIX PHARMACEUTICALS, INC. (US) | 2008-03-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080188440-A1 | Beta-L-2'-Deoxy-Nucleosides for the Treatment of Hepatitis B | PNP, DUT, ATIC | ADORA3 214/4885ADORA2A 102/4885ADORA2B 93/4885 |
| US-20230212213-A1 | A PLATFORM FOR SCREENING NAD+ BINDING PROTEINS IN A CELLULAR CONTEXT | SARM1, PARP16, NAMPT | ADORA3 3744/4885ADORA2A 3458/4885ADORA2B 3989/4885 |
| US-20080064655-A1 | Beta-L-2'-Deoxy-Nucleosides for the Treatment of Hepatitis B | ATIC, SLC35B2, AASDHPPT | ADORA3 147/4885ADORA2A 55/4885ADORA2B 78/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.