Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 6/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | HTT | P42858 | 4/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | PPARA | Q07869 | 3/20 | 0.53 |
| ▸ | ELANE | P08246 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.49 |
| ▸ | PPARD | Q03181 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3873725 | 0.84 | RXRA (0.57) | ALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL11526962 | 0.83 | ALDH1A1 (0.53) | PPARGALDH1A1HTTSMN1; SMN2L3MBTL1 | |
| SCHEMBL10941278 | 0.82 | PPARG (0.53) | PPARGALDH1A1HTTSMN1; SMN2L3MBTL1 | |
| SCHEMBL11472200 | 0.80 | ATM (0.66) | PPARGALDH1A1HTTSMN1; SMN2L3MBTL1 | |
| SCHEMBL23519218 | 0.80 | PPARG (0.51) | PPARGALDH1A1HTTSMN1; SMN2L3MBTL1 | |
| SCHEMBL4711414 | 0.80 | ALDH1A1 (0.60) | PPARGALDH1A1HTTSMN1; SMN2L3MBTL1 | |
| SCHEMBL19604352 | 0.79 | MAPT (0.47) | PPARGALDH1A1HTTSMN1; SMN2L3MBTL1 | |
| SCHEMBL726130 | 0.79 | TSHR (0.52) | ALDH1A1L3MBTL1MAPTCYP2C19 | |
| SCHEMBL5016440 | 0.79 | TSHR (0.52) | ALDH1A1L3MBTL1MAPTCYP2C19 | |
| SCHEMBL15478550 | 0.79 | TRPV1 (0.41) | PPARGALDH1A1SMN1; SMN2RAB9AELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9771320-B2 | Carbocyclic sulfone RORγ modulators | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-09-26 | — | — | US | disclosed |
| US-9771320-B2 | Carbocyclic sulfone RORγ modulators | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-09-26 | — | — | US | disclosed |
| US-20160326103-A1 | CARBOCYCLIC SULFONE ROR GAMMA MODULATORS | BRISTROL-MYERS SQUIBB COMPANY (US) | 2016-11-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160326103-A1 | CARBOCYCLIC SULFONE ROR GAMMA MODULATORS | RORC, RORB, RORA | PPARG 40/4885ALDH1A1 1062/4885HTT 4414/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.