Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | MGLL | Q99685 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1726455 | 0.76 | GRIN2D (0.46) | P2RX7HSD17B10MEN1POLBTHRB | |
| SCHEMBL18214696 | 0.74 | SMN1; SMN2 (0.42) | HSD17B10MEN1POLBTHRBTSHR | |
| SCHEMBL18214723 | 0.73 | BRPF1 (0.43) | MEN1THRBKMT2AALDH1A1KDM4E | |
| SCHEMBL18214707 | 0.72 | TP53 (0.46) | HSD17B10MEN1KMT2AHSP90AA1PARP1 | |
| SCHEMBL7907649 | 0.70 | ALDH1A1 (0.44) | P2RX7HSD17B10MEN1POLBTHRB | |
| SCHEMBL10186595 | 0.69 | POLB (0.41) | HSD17B10MEN1POLBTHRBTSHR | |
| SCHEMBL7905362 | 0.69 | RAB9A (0.42) | P2RX7HSD17B10MEN1POLBTHRB | |
| SCHEMBL17706167 | 0.67 | — | — | |
| SCHEMBL15217072 | 0.66 | — | — | |
| SCHEMBL3274315 | 0.64 | P2RX7 (0.55) | P2RX7MEN1POLBTSHRRECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2404922-B1 | QUINOXALINE COMPOUNDS | ASTELLAS PHARMA INC (JP) | 2016-11-09 | — | — | EP | disclosed |