Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Decoquinate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | SLC19A2 | O60779 | 1/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | CASP1 | P29466 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 5/20 | 0.35 |
| ▸ | RAB9A | P51151 | 5/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 3/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.32 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.32 |
| ▸ | RELA | Q04206 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Decoquinate SCHEMBL29373625 | 0.77 | DPP4 (0.46) | LMNAKDM4ENPC1RAB9AHSD17B10 | |
| Decoquinate SCHEMBL43853 | 0.77 | DPP4 (0.46) | LMNAKDM4ENPC1RAB9AHSD17B10 | |
| Decoquinate SCHEMBL14247781 | 0.75 | DPP4 (0.44) | LMNAKDM4ENPC1RAB9AHSD17B10 | |
| Decoquinate SCHEMBL14247780 | 0.75 | DPP4 (0.44) | LMNANPC1RAB9AHSD17B10SMN1; SMN2 | |
| Decoquinate SCHEMBL15152849 | 0.75 | LMNA (0.47) | LMNAKDM4ENPC1RAB9AHSD17B10 | |
| Amprolium Ion SCHEMBL29910331 | 0.73 | KDM4E (0.98) | LMNAKDM4ESLC19A2USP2CASP1 | |
| Amprolium Ion SCHEMBL362893 | 0.73 | KDM4E (0.98) | LMNAKDM4ESLC19A2USP2CASP1 | |
| Decoquinate SCHEMBL10696854 | 0.73 | DPP4 (0.42) | LMNAKDM4ENPC1RAB9AHSD17B10 | |
| Amprolium Ion SCHEMBL29737311 | 0.73 | KDM4E (1.00) | LMNAKDM4ESLC19A2USP2CASP1 | |
| Amprolium Ion SCHEMBL363586 | 0.73 | KDM4E (0.95) | LMNAKDM4ESLC19A2USP2CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016181187-A1 | COMPOSITION FOR THE TREATMENT OF GREGARINE INFESTATION IN SHRIMP | LABORATORIO AVI-MEX, S.A. DE C.V. (MX) | 2016-11-17 | — | — | WO | disclosed |