Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 3/20 | 0.43 |
| ▸ | SRPK2 | P78362 | 1/20 | 0.43 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.43 |
| ▸ | SRPK3 | Q9UPE1 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 6/20 | 0.42 |
| ▸ | BRAF | P15056 | 3/20 | 0.41 |
| ▸ | RAF1 | P04049 | 2/20 | 0.41 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TEK | Q02763 | 4/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18230422 | 0.92 | LRRK2 (0.56) | LRRK2BRAFRAF1MAPTSMN1; SMN2 | |
| SCHEMBL18230518 | 0.92 | TRPV4 (0.46) | LRRK2KDRADORA3BRAFRAF1 | |
| SCHEMBL18230475 | 0.85 | MAPT (0.45) | LRRK2ADORA3MAPTMEN1KMT2A | |
| SCHEMBL18230441 | 0.84 | LMNA (0.43) | LRRK2ADORA3MAPTMEN1KMT2A | |
| SCHEMBL18230504 | 0.80 | SCD (0.47) | ADORA3MAPTKDM4EMEN1KMT2A | |
| SCHEMBL18230480 | 0.80 | LRRK2 (0.40) | LRRK2ADORA3BRAFRAF1MAPT | |
| SCHEMBL18230296 | 0.80 | TRPV1 (0.54) | ADORA3MAPTKDM4EMEN1KMT2A | |
| SCHEMBL18094518 | 0.79 | MPL (0.46) | LRRK2KDRSRPK2SRPK1SRPK3 | |
| SCHEMBL18230430 | 0.78 | LMNA (0.40) | ADORA3BRAFRAF1MAPTMEN1 | |
| SCHEMBL18230311 | 0.77 | STAT3 (0.47) | ADORA3MAPTALDH1A1LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016183173-A1 | ANTIPARASITIC COMPOUNDS | Avista Pharma Solutions (US) | 2016-11-17 | — | — | WO | disclosed |
| WO-2016183173-A1 | ANTIPARASITIC COMPOUNDS | Avista Pharma Solutions (US) | 2016-11-17 | — | — | WO | disclosed |