Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | STAT3 | P40763 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.41 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MPL | P40238 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18230475 | 0.92 | MAPT (0.45) | LMNAMAPTHTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL18230504 | 0.87 | SCD (0.47) | LMNAMAPTHTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL18230296 | 0.86 | TRPV1 (0.54) | LMNAMAPTHTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL18230430 | 0.84 | LMNA (0.40) | LMNAMAPTHTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL18230362 | 0.84 | LRRK2 (0.45) | LMNAMAPTHTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL18230311 | 0.83 | STAT3 (0.47) | LMNAMAPTHTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL18230422 | 0.82 | LRRK2 (0.56) | MAPTSMN1; SMN2STAT3HDAC1LRRK2 | |
| SCHEMBL18230518 | 0.82 | TRPV4 (0.46) | LMNAMAPTHTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL18230321 | 0.80 | ADORA2A (0.48) | LMNAMAPTHTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL18230513 | 0.79 | TLR7 (0.49) | LMNAMAPTTRPV1ADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016183173-A1 | ANTIPARASITIC COMPOUNDS | Avista Pharma Solutions (US) | 2016-11-17 | — | — | WO | disclosed |
| WO-2016183173-A1 | ANTIPARASITIC COMPOUNDS | Avista Pharma Solutions (US) | 2016-11-17 | — | — | WO | disclosed |