Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 10/20 | 0.56 |
| ▸ | RAF1 | P04049 | 2/20 | 0.51 |
| ▸ | BRAF | P15056 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | STAT3 | P40763 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | BTK | Q06187 | 2/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18230362 | 0.92 | LRRK2 (0.45) | LRRK2RAF1BRAFMAPTSMN1; SMN2 | |
| SCHEMBL18230518 | 0.90 | TRPV4 (0.46) | LRRK2RAF1BRAFMAPTSMN1; SMN2 | |
| SCHEMBL18230475 | 0.84 | MAPT (0.45) | LRRK2MAPTSTAT3SMN1; SMN2HDAC1 | |
| SCHEMBL18230441 | 0.82 | LMNA (0.43) | LRRK2MAPTSTAT3SMN1; SMN2HDAC1 | |
| SCHEMBL18230480 | 0.81 | LRRK2 (0.40) | LRRK2RAF1BRAFMAPT | |
| SCHEMBL18094567 | 0.81 | LRRK2 (0.56) | LRRK2RAF1BRAFMAPTSTAT3 | |
| SCHEMBL18230504 | 0.79 | SCD (0.47) | MAPTSMN1; SMN2 | |
| SCHEMBL18230296 | 0.78 | TRPV1 (0.54) | MAPTSMN1; SMN2 | |
| SCHEMBL18230430 | 0.77 | LMNA (0.40) | RAF1BRAFMAPTSTAT3SMN1; SMN2 | |
| SCHEMBL18230311 | 0.76 | STAT3 (0.47) | MAPTSTAT3SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016183173-A1 | ANTIPARASITIC COMPOUNDS | Avista Pharma Solutions (US) | 2016-11-17 | — | — | WO | disclosed |
| WO-2016183173-A1 | ANTIPARASITIC COMPOUNDS | Avista Pharma Solutions (US) | 2016-11-17 | — | — | WO | disclosed |