Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.31 |
| ▸ | GBA1 | P04062 | 1/20 | 0.31 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14829200 | 0.90 | ALDH1A1 (0.61) | ALDH1A1MAPTL3MBTL1POLBGBA1 | |
| SCHEMBL14829141 | 0.85 | ALDH1A1 (0.44) | ALDH1A1MAPTL3MBTL1POLBSMN1; SMN2 | |
| SCHEMBL11529096 | 0.72 | ALDH1A1 (0.68) | ALDH1A1MAPTL3MBTL1POLBFKBP1A | |
| SCHEMBL3147824 | 0.71 | FKBP1A (0.40) | ALDH1A1MAPTL3MBTL1SMN1; SMN2FKBP1A | |
| SCHEMBL9044246 | 0.71 | HTT (0.42) | ALDH1A1KDM4ELMNAHTTSMN1; SMN2 | |
| SCHEMBL9043612 | 0.71 | POLB (0.46) | ALDH1A1POLBPARP1HTTSMN1; SMN2 | |
| SCHEMBL12741691 | 0.70 | POLB (0.45) | MAPTL3MBTL1POLBHTTSMN1; SMN2 | |
| SCHEMBL9044339 | 0.68 | ALDH1A1 (0.41) | ALDH1A1KDM4EHTTSMN1; SMN2 | |
| SCHEMBL12741676 | 0.68 | P2RX7 (0.39) | L3MBTL1FKBP1A | |
| SCHEMBL316989 | 0.68 | POLB (0.63) | ALDH1A1MAPTL3MBTL1POLBHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2315751-A1 | ALKYNYL ALCOHOLS AS KINASE INHIBITORS | Amgen Inc. (US) | 2011-05-04 | — | — | EP | disclosed |
| WO-2009158011-A1 | ALKYNYL ALCOHOLS AS KINASE INHIBITORS | AMGEN INC. (US) | 2009-12-30 | — | — | WO | disclosed |