Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9043612 | 0.86 | POLB (0.46) | HTTSMN1; SMN2KMT2AALDH1A1HPGD | |
| SCHEMBL9044339 | 0.82 | ALDH1A1 (0.41) | HTTSMN1; SMN2HDAC1KMT2AMEN1 | |
| SCHEMBL9042078 | 0.82 | GRM5 (0.47) | SMN1; SMN2KMT2AMEN1ACHEALDH1A1 | |
| SCHEMBL9041028 | 0.81 | ALDH1A1 (0.58) | HTTSMN1; SMN2KMT2AMEN1ALDH1A1 | |
| SCHEMBL9043663 | 0.71 | L3MBTL1 (0.46) | HTTSMN1; SMN2ALDH1A1LMNAHPGD | |
| SCHEMBL11492920 | 0.71 | FKBP1A (0.48) | SMN1; SMN2KMT2AMEN1CHRM5CHRM1 | |
| SCHEMBL9042445 | 0.71 | LMNA (0.42) | HTTSMN1; SMN2HDAC3HDAC4HDAC1 | |
| SCHEMBL1823633 | 0.71 | ALDH1A1 (0.52) | HTTSMN1; SMN2ALDH1A1LMNAKDM4E | |
| SCHEMBL14829141 | 0.71 | ALDH1A1 (0.44) | SMN1; SMN2ALDH1A1 | |
| SCHEMBL9042862 | 0.70 | L3MBTL1 (0.50) | SMN1; SMN2KMT2AMEN1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0553130-B1 | PYRROLIDINE DIONE DERIVATIVES | PFIZER (US) | 1996-01-03 | — | — | EP | claimed |