Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 1/20 | 0.45 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | MMP9 | P14780 | 1/20 | 0.44 |
| ▸ | GSR | P00390 | 1/20 | 0.41 |
| ▸ | CPB2 | Q96IY4 | 6/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.40 |
| ▸ | ACE | P12821 | 2/20 | 0.38 |
| ▸ | CPB1 | P15086 | 2/20 | 0.38 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.37 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.36 |
| ▸ | TLR2 | O60603 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1824031 | 1.00 | FOLH1 (0.45) | FOLH1MMP2MMP9GSRCPB2 | |
| SCHEMBL8594034 | 0.83 | MME (0.42) | FOLH1CA2ACE | |
| SCHEMBL7605696 | 0.82 | MMP2 (0.49) | FOLH1MMP2MMP9CA1CA2 | |
| SCHEMBL30332077 | 0.81 | FOLH1 (0.45) | FOLH1MMP2MMP9GSRCPB2 | |
| SCHEMBL38654695 | 0.81 | C3AR1 (0.45) | FOLH1MMP2MMP9 | |
| SCHEMBL29024437 | 0.79 | KMT2A (0.43) | FOLH1MMP2MMP9CA1CA2 | |
| SCHEMBL23064407 | 0.79 | FOLH1 (0.40) | FOLH1 | |
| Hydrochloric Acid SCHEMBL7855163 | 0.77 | MMP2 (0.43) | MMP2MMP9ACE | |
| SCHEMBL31549503 | 0.76 | TGFBR1 (0.37) | CA1CA2 | |
| SCHEMBL29631981 | 0.76 | KDM4E (0.42) | FOLH1CA1CA2ACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2256133-B1 | Bioconjugation of macromolecules | SIGMA ALDRICH CO LLC (US) | 2016-12-14 | — | — | EP | disclosed |
| EP-2319854-B1 | Bioconjugation Of Macromolecules | SIGMA ALDRICH CO LLC (US) | 2016-11-30 | — | — | EP | disclosed |
| US-9045552-B2 | Non-viral delivery of compounds to mitochondria | WAKE FOREST UNIVERSITY (US) | 2015-06-02 | — | — | US | disclosed |
| US-8735341-B2 | Non-viral delivery of compounds to mitochondria | WAKE FOREST UNIVERSITY (US) | 2014-05-27 | — | — | US | disclosed |
| US-8283444-B2 | biodrug fusion protein comprising active mitochondrial protein or peptide, a mitochondrial membrane-permeant peptide and linking to a mitochondrial targeting sequence; targeting sequence is cleaved within the mitochondrial matrix, and not cleaved within the cellular cytoplasm; mitochondrial disorders | WAKE FOREST UNIVERSITY (US) | 2012-10-09 | — | — | US | disclosed |
| US-20110245146-A1 | Non-Viral Delivery of Compounds to Mitochondria | PAYNE R MARK | 2011-10-06 | — | — | US | disclosed |
| US-20110190224-A1 | Non-Viral Delivery of Compounds to Mitochondria | PAYNE R MARK | 2011-08-04 | — | — | US | disclosed |
| EP-2319855-A1 | Bioconjugation of Macromolecules | Sigma-Aldrich Co. (US) | 2011-05-11 | — | — | EP | disclosed |
| EP-2319854-A1 | Bioconjugation Of Macromolecules | Sigma-Aldrich Co. (US) | 2011-05-11 | — | — | EP | disclosed |
| EP-2256133-A1 | Bioconjugation of macromolecules | Sigma-Aldrich Co. (US) | 2010-12-01 | — | — | EP | disclosed |
| US-7427678-B2 | Method for immobilizing oligonucleotides employing the cycloaddition bioconjugation method | SIGMA-ALDRICH CO. (US) | 2008-09-23 | — | — | US | disclosed |
| US-20050169904-A1 | Non-viral delivery of compounds to mitochondria | WAKE FOREST UNIVERSITY | 2005-08-04 | — | — | US | disclosed |
| WO-2005042560-A2 | NON-VIRAL DELIVERY OF COMPOUNDS TO MITOCHONDRIA | WAKE FOREST UNIVERSITY HEALTH SCIENCES (US) | 2005-05-12 | — | — | WO | disclosed |
| US-6737236-B1 | DERIVATIZING OLIGONUCLEOTIDES AND PROTEINS USING CYCLOADDITION REACTIONS INCLUDING DIELS-ALDER REACTION OR 1,3-DIPOLAR CYCLOADDITION REACTIONS | PROLIGO, LLC | 2004-05-18 | — | — | US | disclosed |
| US-20030215801-A1 | Method for immobilizing oligonucleotides employing the cycloaddition bioconjugation method | SIGMA-ALDRICH CO., LLC | 2003-11-20 | — | — | US | disclosed |
| EP-1287404-A4 | METHOD FOR IMMOBILIZING OLIGONUCLEOTIDES EMPLOYING THE CYCLOADDITION BIOCONJUGATION METHOD | PROLIGO LLC (US) | 2003-10-15 | — | — | EP | disclosed |
| EP-1287404-A1 | METHOD FOR IMMOBILIZING OLIGONUCLEOTIDES EMPLOYING THE CYCLOADDITION BIOCONJUGATION METHOD | Proligo LLC (US) | 2003-03-05 | — | — | EP | disclosed |
| WO-2001084234-A1 | METHOD FOR IMMOBILIZING OLIGONUCLEOTIDES EMPLOYING THE CYCLOADDITION BIOCONJUGATION METHOD | PROLIGO LLC (US) | 2001-11-08 | — | — | WO | disclosed |
| EP-0968223-A1 | BIOCONJUGATION OF MACROMOLECULES | Proligo L.L.C. (US) | 2000-01-05 | — | — | EP | disclosed |
| WO-1998030575-A1 | BIOCONJUGATION OF MACROMOLECULES | PROLIGO LLC (US) | 1998-07-16 | — | — | WO | disclosed |