Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | TP53 | P04637 | 5/20 | 0.50 |
| ▸ | MAPT | P10636 | 5/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.43 |
| ▸ | TUBB | P07437 | 1/20 | 0.43 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.43 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.43 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.43 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1823504 | 0.91 | TP53 (0.49) | MEN1KMT2ATP53MAPTPOLB | |
| SCHEMBL1827585 | 0.91 | TP53 (0.53) | MEN1KMT2ATP53MAPTPOLB | |
| SCHEMBL1824216 | 0.89 | TP53 (0.49) | MEN1KMT2ATP53MAPTPOLB | |
| SCHEMBL1614386 | 0.89 | TP53 (0.57) | MEN1KMT2ATP53MAPTPOLB | |
| SCHEMBL1826130 | 0.85 | TP53 (0.44) | MEN1KMT2ATP53MAPTPOLB | |
| SCHEMBL1823976 | 0.85 | MEN1 (0.43) | MEN1KMT2ATP53MAPTPOLB | |
| SCHEMBL1825571 | 0.84 | ALDH1A1 (0.50) | KMT2ATP53MAPTPOLBALDH1A1 | |
| SCHEMBL1824682 | 0.84 | ALDH1A1 (0.47) | MEN1KMT2ATP53POLBALDH1A1 | |
| SCHEMBL1824783 | 0.84 | MAPT (0.44) | MEN1KMT2ATP53MAPTPOLB | |
| SCHEMBL1822868 | 0.83 | TP53 (0.43) | MEN1KMT2ATP53MAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1794122-B1 | 3-SUBSTITUTED-5- AND 6-AMINOALKYL INDOLE-2-CARBOXYLIC ACID AMIDES AND RELATED ANALOGS AS INHIBITORS OF CASEIN KINASE I | AVENTIS PHARMA INC (US) | 2011-05-04 | — | — | EP | claimed |