SCHEMBL18248055

SCHEMBL18248055

CN(C(=O)OC(C)(C)C)C(CC(C)(C)F)C(=O)O

nearest known ligand 0.37

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
▸ MMP13 P45452 1/20 0.37
▸ AAK1 Q2M2I8 2/20 0.34
▸ CA14 Q9ULX7 1/20 0.34
▸ MEN1 O00255 1/20 0.32
▸ GAA P10253 1/20 0.32
▸ KMT2A Q03164 1/20 0.32
▸ APLNR P35414 1/20 0.31
▸ HDAC1 Q13547 1/20 0.31
▸ HDAC2 Q92769 1/20 0.31
▸ HDAC6 Q9UBN7 1/20 0.31
▸ CTSK P43235 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18248003 1.00 MMP13 (0.37) MMP13AAK1CA14MEN1GAA
SCHEMBL28815034 0.90 MMP13 (0.37) MMP13AAK1CA14MEN1GAA
SCHEMBL18248197 0.90 MMP13 (0.37) MMP13AAK1CA14MEN1GAA
SCHEMBL18248032 0.90 MMP13 (0.37) MMP13AAK1CA14MEN1GAA
SCHEMBL29655548 0.89 CA14 (0.32) MMP13CA14
SCHEMBL19088491 0.87 AAK1 (0.34) MMP13AAK1CA14HDAC1HDAC2
SCHEMBL68033 0.86 MMP13 (0.38) MMP13AAK1MEN1GAAKMT2A
SCHEMBL68034 0.86 MMP13 (0.38) MMP13AAK1MEN1GAAKMT2A
SCHEMBL20586574 0.85 MMP13 (0.38) MMP13AAK1MEN1GAAKMT2A
SCHEMBL18248156 0.85 MMP13 (0.38) MMP13AAK1MEN1GAAKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12286455-B2 Anthelmintic depsipeptide compounds Boehringer Ingelheim Animal Health USA Inc. (US) 2025-04-29 — — US disclosed
US-12018048-B2 Anthelmintic depsipeptide compounds Boehringer Ingelheim Animal Health USA Inc. (US) 2024-06-25 — — US disclosed
US-11993600-B2 Saturated spirocyclics as antiviral agents ENANTA PHARMACEUTICALS, INC. (US) 2024-05-28 — — US disclosed
EP-3397638-B1 ANTHELMINTIC DEPSIPEPTIDE COMPOUNDS BOEHRINGER INGELHEIM ANIMAL HEALTH USA INC (US) 2023-08-23 — — EP disclosed
WO-2023107419-A1 SATURATED SPIROCYCLICS AS ANTIVIRAL AGENTS ENANTA PHARMACEUTICALS, INC. (US) 2023-06-15 — — WO disclosed
US-20230174531-A1 SATURATED SPIROCYCLICS AS ANTIVIRAL AGENTS ENANTA PHARMACEUTICALS, INC. 2023-06-08 — — US disclosed
CN-114891070-A Anthelmintic depsipeptide compounds 勃林格殷格翰动物保健美国公司 2022-08-12 — — CN disclosed
US-11382949-B2 Anthelmintic depsipeptide compounds Boehringer Ingelheim Animal Health USA Inc. (US) 2022-07-12 — — US disclosed
US-11382949-B2 Anthelmintic depsipeptide compounds Boehringer Ingelheim Animal Health USA Inc. (US) 2022-07-12 — — US disclosed
CN-108699052-B Anthelmintic depsipeptide compounds 勃林格殷格翰动物保健美国公司 2022-04-29 — — CN disclosed
US-10344056-B2 Anthelmintic depsipeptide compounds Boehringer Ingelheim Animal Health USA Inc. (US) 2019-07-09 — — US disclosed
US-20180362589-A1 ANTHELMINTIC DEPSIPEPTIDE COMPOUNDS MERIAL INC. (US) 2018-12-20 — — US disclosed
EP-3397638-A1 ANTHELMINTIC DEPSIPEPTIDE COMPOUNDS Merial, Inc. (US) 2018-11-07 — — EP disclosed
US-10081656-B2 Anthelmintic depsipeptide compounds MERIAL, INC. (US) 2018-09-25 — — US disclosed
WO-2018093920-A1 ANTHELMINTIC DEPSIPEPTIDE COMPOUNDS MERIAL, INC. (US) 2018-05-24 — — WO disclosed
EP-3298027-A1 ANTHELMINTIC DEPSIPEPTIDE COMPOUNDS Merial, Inc. (US) 2018-03-28 — — EP disclosed
US-20170233438-A1 ANTHELMINTIC DEPSIPEPTIDE COMPOUNDS MERIAL INC. (US) 2017-08-17 — — US disclosed
WO-2017116702-A1 ANTHELMINTIC DEPSIPEPTIDE COMPOUNDS MERIAL, INC. (US) 2017-07-06 — — WO disclosed
US-20170022253-A1 ANTHELMINTIC DEPSIPEPTIDE COMPOUNDS MERIAL INC. (US) 2017-01-26 — — US disclosed
WO-2016187534-A1 ANTHELMINTIC DEPSIPEPTIDE COMPOUNDS MERIAL, INC. (US) 2016-11-24 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10344056-B2 Anthelmintic depsipeptide compounds VIP, PREP, DNPEP MMP13 440/4885AAK1 3436/4885CA14 1978/4885
US-12018048-B2 Anthelmintic depsipeptide compounds VIP, DNPEP, DPEP1 MMP13 434/4885AAK1 3150/4885CA14 1962/4885
US-20170022253-A1 ANTHELMINTIC DEPSIPEPTIDE COMPOUNDS VIP, PREP, DNPEP MMP13 504/4885AAK1 3412/4885CA14 1955/4885
US-11993600-B2 Saturated spirocyclics as antiviral agents ACE, ACE2, PKD1 MMP13 3662/4885AAK1 3349/4885CA14 2098/4885
US-11382949-B2 Anthelmintic depsipeptide compounds ENPP2, ROCK2, RRP12 MMP13 1446/4885AAK1 3576/4885CA14 2150/4885
US-20170233438-A1 ANTHELMINTIC DEPSIPEPTIDE COMPOUNDS VIP, PREP, DNPEP MMP13 440/4885AAK1 3436/4885CA14 1978/4885
US-20180362589-A1 ANTHELMINTIC DEPSIPEPTIDE COMPOUNDS VIP, PREP, DNPEP MMP13 504/4885AAK1 3412/4885CA14 1955/4885
US-10081656-B2 Anthelmintic depsipeptide compounds VIP, PREP, DNPEP MMP13 504/4885AAK1 3412/4885CA14 1955/4885
US-20230174531-A1 SATURATED SPIROCYCLICS AS ANTIVIRAL AGENTS ACE, ACE2, PKD1 MMP13 3662/4885AAK1 3349/4885CA14 2098/4885
US-12286455-B2 Anthelmintic depsipeptide compounds VIP, PREP, DNPEP MMP13 504/4885AAK1 3412/4885CA14 1955/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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