SCHEMBL18256297

SCHEMBL18256297

C[C@@H](OC(=O)[C@H](CC(C)(C)F)N(C)C(=O)OC(C)(C)C)C(=O)OCc1ccccc1

nearest known ligand 0.41

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ MMP13 P45452 1/20 0.38
▸ L3MBTL1 Q9Y468 3/20 0.38
▸ SYK P43405 1/20 0.38
▸ POLB P06746 1/20 0.37
▸ CTSL P07711 2/20 0.37
▸ CTSB P07858 1/20 0.37
▸ CTSS P25774 1/20 0.37
▸ CTSK P43235 1/20 0.37
▸ ABCB1 P08183 1/20 0.35
▸ REN P00797 1/20 0.35
▸ ALDH1A1 P00352 2/20 0.35
▸ NPSR1 Q6W5P4 1/20 0.35
▸ MAPT P10636 1/20 0.34
▸ HPGD P15428 1/20 0.34
▸ LMNA P02545 1/20 0.34
▸ SMN1; SMN2 Q16637 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18248065 1.00 MMP13 (0.38) MMP13L3MBTL1SYKPOLBCTSL
SCHEMBL24093690 1.00 MMP13 (0.38) MMP13L3MBTL1SYKPOLBCTSL
SCHEMBL18248145 0.91 MMP13 (0.39) MMP13L3MBTL1SYKPOLBCTSL
SCHEMBL23269885 0.91 MMP13 (0.39) MMP13L3MBTL1SYKPOLBCTSL
SCHEMBL18248147 0.91 MMP13 (0.39) MMP13L3MBTL1SYKPOLBCTSL
SCHEMBL22502801 0.90 CTSK (0.38) MMP13L3MBTL1SYKPOLBCTSL
SCHEMBL24093764 0.89 MMP13 (0.38) MMP13L3MBTL1SYKPOLBABCB1
SCHEMBL22651691 0.89 POLB (0.37) MMP13POLBNPSR1HPGDLMNA
SCHEMBL23279588 0.88 ALDH1A1 (0.40) L3MBTL1CTSLCTSBCTSSCTSK
SCHEMBL18256486 0.88 ABCB1 (0.41) MMP13L3MBTL1SYKPOLBABCB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12286455-B2 Anthelmintic depsipeptide compounds Boehringer Ingelheim Animal Health USA Inc. (US) 2025-04-29 — — US disclosed
US-11382949-B2 Anthelmintic depsipeptide compounds Boehringer Ingelheim Animal Health USA Inc. (US) 2022-07-12 — — US disclosed
US-11382949-B2 Anthelmintic depsipeptide compounds Boehringer Ingelheim Animal Health USA Inc. (US) 2022-07-12 — — US disclosed
EP-3922639-A1 ANTHELMINTIC DEPSIPEPTIDE COMPOUNDS Boehringer Ingelheim Animal Health USA Inc. (US) 2021-12-15 — — EP disclosed
EP-3298027-B1 ANTHELMINTIC DEPSIPEPTIDE COMPOUNDS BOEHRINGER INGELHEIM ANIMAL HEALTH USA INC (US) 2021-04-28 — — EP disclosed
US-20200354408-A1 ANTHELMINTIC DEPSIPEPTIDE COMPOUNDS Boehringer Ingelheim Animal Health USA Inc. (US) 2020-11-12 — — US disclosed
US-10793604-B2 Anthelmintic depsipeptide compounds Boehringer Ingelheim Animal Health USA Inc. (US) 2020-10-06 — — US disclosed
US-20190307838-A1 ANTHELMINTIC DEPSIPEPTIDE COMPOUNDS Boehringer Ingelheim Animal Health USA Inc. (US) 2019-10-10 — — US disclosed
US-20170022253-A1 ANTHELMINTIC DEPSIPEPTIDE COMPOUNDS MERIAL INC. (US) 2017-01-26 — — US disclosed
WO-2016187534-A1 ANTHELMINTIC DEPSIPEPTIDE COMPOUNDS MERIAL, INC. (US) 2016-11-24 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170022253-A1 ANTHELMINTIC DEPSIPEPTIDE COMPOUNDS VIP, PREP, DNPEP MMP13 504/4885L3MBTL1 524/4885SYK 3404/4885
US-11382949-B2 Anthelmintic depsipeptide compounds ENPP2, ROCK2, RRP12 MMP13 1446/4885L3MBTL1 2308/4885SYK 1165/4885
US-10793604-B2 Anthelmintic depsipeptide compounds VIP, PREP, DNPEP MMP13 504/4885L3MBTL1 524/4885SYK 3404/4885
US-20190307838-A1 ANTHELMINTIC DEPSIPEPTIDE COMPOUNDS ENPP2, ROCK2, RRP12 MMP13 1446/4885L3MBTL1 2308/4885SYK 1165/4885
US-20200354408-A1 ANTHELMINTIC DEPSIPEPTIDE COMPOUNDS VIP, PREP, DNPEP MMP13 504/4885L3MBTL1 524/4885SYK 3404/4885
US-12286455-B2 Anthelmintic depsipeptide compounds VIP, PREP, DNPEP MMP13 504/4885L3MBTL1 524/4885SYK 3404/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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