SCHEMBL18256324

SCHEMBL18256324

CC(C)C[C@@H](C(=O)O[C@H](C)C(=O)OCc1ccccc1)N(C)C(=O)OC(C)(C)C

nearest known ligand 0.46

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ CTSK P43235 5/20 0.46
▸ CTSB P07858 2/20 0.46
▸ CTSL P07711 1/20 0.46
▸ CTSS P25774 1/20 0.46
▸ AAK1 Q2M2I8 2/20 0.43
▸ REN P00797 1/20 0.42
▸ MAPT P10636 1/20 0.40
▸ XBP1 P17861 1/20 0.40
▸ NPSR1 Q6W5P4 1/20 0.40
▸ TDP1 Q9NUW8 1/20 0.40
▸ MMP13 P45452 1/20 0.39
▸ SYK P43405 1/20 0.39
▸ L3MBTL1 Q9Y468 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19066731 1.00 CTSK (0.46) CTSKCTSBCTSLCTSSAAK1
SCHEMBL18248083 1.00 CTSK (0.46) CTSKCTSBCTSLCTSSAAK1
SCHEMBL21447947 1.00 CTSK (0.46) CTSKCTSBCTSLCTSSAAK1
SCHEMBL21447763 1.00 CTSK (0.46) CTSKCTSBCTSLCTSSAAK1
SCHEMBL13519510 0.92 CTSK (0.48) CTSKCTSBCTSLCTSSAAK1
SCHEMBL27853178 0.92 CTSK (0.48) CTSKCTSBCTSLCTSSAAK1
SCHEMBL22651717 0.90 CTSK (0.41) CTSKCTSBCTSLCTSSAAK1
SCHEMBL23269885 0.89 MMP13 (0.39) CTSKCTSBCTSLCTSSREN
SCHEMBL18248147 0.89 MMP13 (0.39) CTSKCTSBCTSLCTSSREN
SCHEMBL18248145 0.89 MMP13 (0.39) CTSKCTSBCTSLCTSSREN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 51 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3676265-B1 METHOD FOR THE SYNTHESIS OF CYCLIC DEPSIPEPTIDES ELANCO ANIMAL HEALTH GMBH (DE) 2025-08-20 — — EP disclosed
EP-3790876-B1 ENDOPARASITIC DEPSIPEPTIDES ZOETIS SERVICES LLC (US) 2025-04-30 — — EP disclosed
US-12286455-B2 Anthelmintic depsipeptide compounds Boehringer Ingelheim Animal Health USA Inc. (US) 2025-04-29 — — US disclosed
US-20250019360-A1 METHOD FOR THE SYNTHESIS OF CYCLIC DEPSIPEPTIDES ELANCO ANIMAL HEALTH GMBH (DE) 2025-01-16 — — US disclosed
US-12122759-B2 Method for the synthesis of cyclic depsipeptides ELANCO ANIMAL HEALTH GMBH (DE) 2024-10-22 — — US disclosed
US-12018048-B2 Anthelmintic depsipeptide compounds Boehringer Ingelheim Animal Health USA Inc. (US) 2024-06-25 — — US disclosed
US-12018048-B2 Anthelmintic depsipeptide compounds Boehringer Ingelheim Animal Health USA Inc. (US) 2024-06-25 — — US disclosed
US-12018048-B2 Anthelmintic depsipeptide compounds Boehringer Ingelheim Animal Health USA Inc. (US) 2024-06-25 — — US disclosed
CN-112384511-B Endoparasite depsipeptides 硕腾服务有限责任公司 2024-01-30 — — CN disclosed
US-11786575-B2 Endoparasitic depsipeptides ZOETIS SERVICES LLC (US) 2023-10-17 — — US disclosed
US-10344056-B2 Anthelmintic depsipeptide compounds Boehringer Ingelheim Animal Health USA Inc. (US) 2019-07-09 — — US disclosed
US-10344056-B2 Anthelmintic depsipeptide compounds Boehringer Ingelheim Animal Health USA Inc. (US) 2019-07-09 — — US disclosed
EP-3397638-A1 ANTHELMINTIC DEPSIPEPTIDE COMPOUNDS Merial, Inc. (US) 2018-11-07 — — EP disclosed
US-20170233438-A1 ANTHELMINTIC DEPSIPEPTIDE COMPOUNDS MERIAL INC. (US) 2017-08-17 — — US disclosed
US-20170233438-A1 ANTHELMINTIC DEPSIPEPTIDE COMPOUNDS MERIAL INC. (US) 2017-08-17 — — US disclosed
US-20170233438-A1 ANTHELMINTIC DEPSIPEPTIDE COMPOUNDS MERIAL INC. (US) 2017-08-17 — — US disclosed
WO-2017116702-A1 ANTHELMINTIC DEPSIPEPTIDE COMPOUNDS MERIAL, INC. (US) 2017-07-06 — — WO disclosed
WO-2017116702-A1 ANTHELMINTIC DEPSIPEPTIDE COMPOUNDS MERIAL, INC. (US) 2017-07-06 — — WO disclosed
US-20170022253-A1 ANTHELMINTIC DEPSIPEPTIDE COMPOUNDS MERIAL INC. (US) 2017-01-26 — — US disclosed
WO-2016187534-A1 ANTHELMINTIC DEPSIPEPTIDE COMPOUNDS MERIAL, INC. (US) 2016-11-24 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10344056-B2 Anthelmintic depsipeptide compounds VIP, PREP, DNPEP CTSK 185/4885CTSB 118/4885CTSL 129/4885
US-12018048-B2 Anthelmintic depsipeptide compounds VIP, DNPEP, DPEP1 CTSK 111/4885CTSB 78/4885CTSL 77/4885
US-20170022253-A1 ANTHELMINTIC DEPSIPEPTIDE COMPOUNDS VIP, PREP, DNPEP CTSK 204/4885CTSB 101/4885CTSL 86/4885
US-11786575-B2 Endoparasitic depsipeptides VIP, PREP, NGLY1 CTSK 518/4885CTSB 143/4885CTSL 75/4885
US-20170233438-A1 ANTHELMINTIC DEPSIPEPTIDE COMPOUNDS VIP, PREP, DNPEP CTSK 185/4885CTSB 118/4885CTSL 129/4885
US-12122759-B2 Method for the synthesis of cyclic depsipeptides DNPEP, NPEPPS, PREP CTSK 669/4885CTSB 690/4885CTSL 799/4885
US-20250019360-A1 METHOD FOR THE SYNTHESIS OF CYCLIC DEPSIPEPTIDES DNPEP, NPEPPS, PREP CTSK 669/4885CTSB 690/4885CTSL 799/4885
US-12286455-B2 Anthelmintic depsipeptide compounds VIP, PREP, DNPEP CTSK 204/4885CTSB 101/4885CTSL 86/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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