Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.45 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | SYK | P43405 | 1/20 | 0.43 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.43 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL180361 | 0.78 | DGAT1 (0.81) | DGAT1MAPTGAASYKADRB1 | |
| SCHEMBL1722009 | 0.76 | DGAT1 (0.60) | DGAT1CAMK2DMEN1KMT2APKM | |
| SCHEMBL4201881 | 0.71 | ABCC4 (0.67) | GAAPDE4BPDE4DADRB1ADRB3 | |
| SCHEMBL21311893 | 0.70 | HSD17B1 (0.57) | MAPTMEN1KMT2APKMSYK | |
| SCHEMBL181030 | 0.68 | DGAT1 (1.00) | DGAT1SYKFFAR1KDR | |
| SCHEMBL22649136 | 0.68 | PDE4B (0.57) | PDE4BPDE4DSYKCYP3A4CYP2C19 | |
| SCHEMBL21311909 | 0.67 | ENPP3 (0.48) | MAPTGAAMEN1KMT2APKM | |
| SCHEMBL181014 | 0.65 | CYP1A1 (0.62) | MAPTMEN1KMT2ANPC1RAB9A | |
| SCHEMBL4217521 | 0.65 | SELP (0.49) | MAPTGAAMEN1KMT2AADRB3 | |
| SCHEMBL4211639 | 0.65 | ABCC4 (0.69) | MAPTGAAPDE4BPDE4DFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2402320-A1 | Anorectic agents | Novartis AG (CH) | 2012-01-04 | — | — | EP | disclosed |