SCHEMBL18263202

SCHEMBL18263202

O=[N+]([O-])c1ccc(S(=O)(=O)Oc2c(Br)cccc2Br)cc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA2 P00918 9/20 0.49
CA1 P00915 7/20 0.49
CA9 Q16790 7/20 0.49
CA12 O43570 6/20 0.49
CA14 Q9ULX7 4/20 0.49
CA5A P35218 4/20 0.49
CA7 P43166 4/20 0.49
CA3 P07451 3/20 0.49
CA4 P22748 3/20 0.49
CA6 P23280 3/20 0.49
CA13 Q8N1Q1 3/20 0.49
CA5B Q9Y2D0 3/20 0.49
ALDH1A1 P00352 1/20 0.45
HSP90AA1 P07900 1/20 0.45
ALPL P05186 1/20 0.43
ALPI P09923 1/20 0.43
P2RY2 P41231 1/20 0.41
GPR17 Q13304 1/20 0.41
HTT P42858 2/20 0.41
KMT2A Q03164 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL929164 0.82 ALPL (0.53) CA2CA1CA9CA12CA14
SCHEMBL18263184 0.78 ALDH1A1 (0.51) CA2CA1CA9CA12CA5A
SCHEMBL29052062 0.78 PAX8 (0.44) ALDH1A1GPR17HTTKMT2AGAA
SCHEMBL15022229 0.77 CA1 (0.47) CA2CA1CA9CA12CA14
SCHEMBL1500136 0.75 ALDH1A1 (0.43) CA2CA1CA9CA12CA14
SCHEMBL28216404 0.75 ALDH1A1 (0.39) CA2CA1CA9CA12CA14
SCHEMBL28216405 0.75 ALDH1A1 (0.39) CA2CA1CA9CA12CA14
SCHEMBL11041999 0.75 HTT (0.59) CA2CA1CA9CA12CA14
SCHEMBL927603 0.74 ALDH1A1 (0.57) CA2CA1CA9CA12CA14
SCHEMBL14594621 0.73 HTT (0.62) CA2CA1CA9CA12CA14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107108416-B Preparation method of 1, 2-dicyclopropylethylphenol and optical isomer thereof 四川海思科制药有限公司 2019-12-20 CN disclosed
CN-107108416-A A kind of preparation method of 1,2 Bicyclopropyl ethyl -phenol and its optical isomer 四川海思科制药有限公司 2017-08-29 CN disclosed
WO-2016188490-A1 METHOD FOR PREPARING 1,2-DICYCLOPROPYLETHYLPHENOL AND OPTICAL ISOMER THEREOF 四川海思科制药有限公司 2016-12-01 WO disclosed
WO-2016188490-A1 METHOD FOR PREPARING 1,2-DICYCLOPROPYLETHYLPHENOL AND OPTICAL ISOMER THEREOF 四川海思科制药有限公司 2016-12-01 WO disclosed