SCHEMBL182687

SCHEMBL182687

O=C(O)c1n[nH]cc1[N+](=O)[O-]

nearest known ligand 0.41

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.41
CASP6 P55212 2/20 0.40
HCAR3 P49019 1/20 0.38
GPR35 Q9HC97 1/20 0.37
TSHR P16473 3/20 0.37
CA1 P00915 1/20 0.37
CA2 P00918 1/20 0.37
TDP1 Q9NUW8 1/20 0.37
L3MBTL1 Q9Y468 1/20 0.37
TPMT P51580 1/20 0.37
DNA2 P51530 1/20 0.36
CTDSP1 Q9GZU7 1/20 0.36
KDM4E B2RXH2 1/20 0.36
ASPH Q12797 1/20 0.36
KDM8 Q8N371 1/20 0.36
DTYMK P23919 1/20 0.36
APEX1 P27695 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Propane SCHEMBL18131179 0.93 HCAR3 (0.38) LMNACASP6HCAR3TSHRTDP1
SCHEMBL3060652 0.82 GPR35 (0.40) LMNACASP6GPR35TSHRTDP1
SCHEMBL3431418 0.82 KCNMA1 (0.43) LMNAGPR35TSHRTDP1L3MBTL1
SCHEMBL546991 0.81 NPSR1 (0.43) LMNATSHRTDP1KDM4E
SCHEMBL7514225 0.79 KMT2A (0.49) LMNAHCAR3GPR35L3MBTL1KDM4E
SCHEMBL13375198 0.79 ALDH1A1 (0.40) LMNAGPR35L3MBTL1KDM4E
SCHEMBL10240268 0.79 GPR35 (0.34) LMNAGPR35TSHRTDP1KDM4E
Hydrochloric Acid SCHEMBL3467163 0.79 NPSR1 (0.42) LMNATSHRTDP1KDM4E
SCHEMBL13543760 0.78 SLC6A2 (0.40) LMNAHCAR3L3MBTL1
SCHEMBL7760011 0.77 PRSS1 (0.39) GPR35KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 709 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4661890-A1 PTP1B/TC-PTP DUAL INHIBITORS AND PROTEIN DEGRADERS Purdue Research Foundation (US) 2025-12-17 EP claimed
CN-119082814-A Stabilizer for cyanide-free gold plating and application thereof 重庆立道新材料科技有限公司 2024-12-06 CN claimed
WO-2024167565-A1 PTP1B/TC-PTP DUAL INHIBITORS AND PROTEIN DEGRADERS PURDUE RESEARCH FOUNDATION (US) 2024-08-15 WO claimed
CN-110208242-B Gel material for rapid detection of pesticide and preparation method and application thereof 上海应用技术大学 2021-09-28 CN claimed
US-10072043-B2 Inhibitors of protein tyrosine phosphatases INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) 2018-09-11 US claimed
US-9486892-B2 Polishing composition FUJIMI INCORPORATED (JP) 2016-11-08 US claimed
US-20160176922-A1 INHIBITORS OF PROTEIN TYROSINE PHOSPHATASES Indiana University Research and Technology Corpora tion (US) 2016-06-23 US claimed
US-9217012-B2 Inhibitors of protein tyrosine phosphatases INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) 2015-12-22 US claimed
US-20120088720-A1 INHIBITORS OF PROTEIN TYROSINE PHOSPHATASES INDIANA UNIVERSITY RESEARCH & TECHNOLOGY CORPORATI (US) 2012-04-12 US claimed
WO-2010118241-A2 INHIBITORS OF PROTEIN TYROSINE PHOSPHATASES INDIANA UNIVERSITY RESEARCH & TECHNOLOGY CORPORATION (US) 2010-10-14 WO claimed
EP-3886904-B1 IRAK DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS INC (US) 2026-04-22 EP disclosed
US-12551555-B2 Compositions and methods for potentiating immune activity KUMQUAT BIOSCIENCES INC. (US) 2026-02-17 US disclosed
US-12534440-B2 Compounds with copper- or zinc-activated toxicity against microbial infection KANSAS STATE UNIVERSITY RESEARCH FOUNDATION (US) 2026-01-27 US disclosed
EP-4661890-A1 PTP1B/TC-PTP DUAL INHIBITORS AND PROTEIN DEGRADERS Purdue Research Foundation (US) 2025-12-17 EP disclosed
US-20250325673-A1 IRAK DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS INC (US) 2025-10-23 US disclosed
EP-1181266-A1 SQUARIC ACID DERIVATIVES AS CELL ADHESION MOLECULES Celltech R&D Limited (GB) 2002-02-27 EP disclosed
CN-1314913-A Targeted combinatorial compound libraries and efficient assays for screening GLYCODESIGN INC (CA) 2001-09-26 CN disclosed
EP-1086064-A2 DIRECTED COMBINATORIAL COMPOUND LIBRARY AND HIGH THROUGHPUT ASSAYS FOR SCREENING SAME Glycodesign Inc. (CA) 2001-03-28 EP disclosed
WO-2000073260-A1 SQUARIC ACID DERIVATIVES AS CELL ADHESION MOLECULES CELLTECH R&D LIMITED (GB) 2000-12-07 WO disclosed
WO-1999064378-A2 DIRECTED COMBINATORIAL COMPOUND LIBRARY AND HIGH THROUGHPUT ASSAYS FOR SCREENING SAME GLYCODESIGN INC. (CA) 1999-12-16 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250325673-A1 IRAK DEGRADERS AND USES THEREOF IRAK2, IRAK3, IRAK1 LMNA 1656/4885CASP6 323/4885HCAR3 763/4885
US-10072043-B2 Inhibitors of protein tyrosine phosphatases PTPRCAP, PTPRF, PTPRS LMNA 4734/4885CASP6 3234/4885HCAR3 4635/4885
US-12534440-B2 Compounds with copper- or zinc-activated toxicity against microbial infection TST, SLC39A11, SLC39A3 LMNA 4549/4885CASP6 3009/4885HCAR3 4054/4885
US-12551555-B2 Compositions and methods for potentiating immune activity PTPRCAP, PTPN2, PTPRC LMNA 4799/4885CASP6 2192/4885HCAR3 4180/4885
US-20160176922-A1 INHIBITORS OF PROTEIN TYROSINE PHOSPHATASES PTPRCAP, PTPRF, PTPRS LMNA 4734/4885CASP6 3234/4885HCAR3 4635/4885
US-20120088720-A1 INHIBITORS OF PROTEIN TYROSINE PHOSPHATASES PTPRCAP, PTPRF, PTPRS LMNA 4734/4885CASP6 3234/4885HCAR3 4635/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.