Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Adamantane. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.31 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.31 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.31 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.31 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Alcohol SCHEMBL3467099 | 0.85 | ALDH1A1 (0.43) | ALDH1A1TSHR | |
| Alcohol SCHEMBL3285235 | 0.85 | ALDH1A1 (0.43) | ALDH1A1TSHRCYP2C9 | |
| Adamantane SCHEMBL6037700 | 0.78 | TSHR (0.46) | TSHRCYP2C9EPHX2HSD11B1 | |
| Adamantane SCHEMBL1071737 | 0.78 | L3MBTL1 (0.37) | CYP2C9L3MBTL1EPHX2CHRNB2CHRNB4 | |
| Adamantane SCHEMBL1154916 | 0.77 | CYP2C9 (0.47) | TSHRCYP2C9L3MBTL1EPHX2HSD11B1 | |
| Adamantane SCHEMBL7737478 | 0.75 | GRIN2D (0.40) | TSHRCYP2C9L3MBTL1 | |
| Adamantane SCHEMBL15536146 | 0.75 | ALDH1A1 (0.50) | ALDH1A1CYP2C9L3MBTL1 | |
| Alcohol SCHEMBL1321514 | 0.71 | — | — | |
| Alcohol SCHEMBL8333259 | 0.71 | — | — | |
| Alcohol SCHEMBL28777127 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 208 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118546393-A | Self-adaptive self-healing hydrogel and preparation method and application thereof | 思味趣生物科技(上海)有限公司 | 2024-08-27 | — | — | CN | claimed |
| CN-117736100-A | Preparation method of diphenylamine adamantane substituent compound | 维思普新材料（苏州）有限公司 | 2024-03-22 | — | — | CN | claimed |
| CN-108285439-B | Carbonoside sodium glucose transport protein body 2 inhibitor | 江苏天士力帝益药业有限公司 | 2023-05-02 | — | — | CN | claimed |
| CN-113897109-A | Diatomite grafted polyurea modified humidity-regulating water-based acrylic coating and preparation method thereof | 深圳市悟净贸易有限公司 | 2022-01-07 | — | — | CN | claimed |
| CN-104725194-B | A kind of preparation method of adamantane alcohol compound | 泸州大洲化工有限公司 | 2016-08-17 | — | — | CN | claimed |
| CN-104725194-A | Preparation method of adamantanol compound | LUZHOU DAZHOU CHEMICAL CO LTD | 2015-06-24 | — | — | CN | claimed |
| US-8598292-B2 | Adamantane derivative, method for producing same, polymer using same as starting material, and resin composition | MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) | 2013-12-03 | — | — | US | claimed |
| US-8481016-B2 | Method for inhibition of potential-dependent cation channel | KAO CORPORATION (JP) | 2013-07-09 | — | — | US | claimed |
| US-20130045177-A1 | Method for Inhibition of Potential-Dependent Cation Channel | KAO CORPORATION (JP) | 2013-02-21 | — | — | US | claimed |
| US-20110319584-A1 | ADAMANTANE DERIVATIVE, METHOD FOR PRODUCING SAME, POLYMER USING SAME AS STARTING MATERIAL, AND RESIN COMPOSITION | MITSUBISHI GAS CHEMICAL COMPANY, INC (JP) | 2011-12-29 | — | — | US | claimed |
| US-20070141508-A1 | Negative resist composition and method for forming resist pattern | TOKYO OHKA KOGYO CO., LTD. (JP) | 2007-06-21 | — | — | US | claimed |
| US-20060134545-A1 | Negative resist composition and process for formation of resist patterns | TOKYO OHKA KOGYO CO., LTD. (JP) | 2006-06-22 | — | — | US | claimed |
| US-6797745-B1 | Hot melt inks containing styrene or terpene polymers | XEROX CORPORATION | 2004-09-28 | — | — | US | claimed |
| US-5922117-A | Ink compositions containing alcohols | XEROX CORPORATION (US) | 1999-07-13 | — | — | US | claimed |
| JP-57079187-A | — | — | None | — | — | JP | disclosed |
| JP-8259533-A | — | — | None | — | — | JP | disclosed |
| WO-2024177174-A1 | INK COMPOSITION COMPRISING CORE-SHELL-STRUCTURED METAL OXIDE | 한남대학교 산학협력단 | 2024-08-29 | — | — | WO | disclosed |
| EP-0668290-A1 | Physiologically active substance well capable of permeating biomembrane | TEIKOKU SEIYAKU CO., LTD. (JP) | 1995-08-23 | — | — | EP | disclosed |
| EP-0516851-A1 | PHYSIOLOGICALLY ACTIVE SUBSTANCE WELL CAPABLE OF PERMEATING BIOMEMBRANE | TEIKOKU SEIYAKU KABUSHIKI KAISHA (JP) | 1992-12-09 | — | — | EP | disclosed |
| JP-S5779187-A | MANUFACTURE OF PERFLUORO(ALKYL-SUBSTITUTED ADAMANTANE) | AGENCY OF IND SCIENCE & TECHNOL | 1982-05-18 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130045177-A1 | Method for Inhibition of Potential-Dependent Cation Channel | TRPM7, TRPM8, OR10J3 | ALDH1A1 844/4885TSHR 1275/4885CYP2C9 795/4885 |
| US-20110319584-A1 | ADAMANTANE DERIVATIVE, METHOD FOR PRODUCING SAME, POLYMER USING SAME AS STARTING MATERIAL, AND RESIN COMPOSITION | EEF1A1, ADGRF1, ERCC4 | ALDH1A1 457/4885TSHR 3042/4885CYP2C9 3737/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.