Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.37 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.35 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ALOX5AP | P20292 | 10/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17008778 | 1.00 | HCAR2 (0.37) | HCAR2TRPV4HRH3TBXA2RSMN1; SMN2 | |
| SCHEMBL18279752 | 0.88 | TRPV4 (0.33) | HCAR2TRPV4HRH3TBXA2RGRIN2B | |
| SCHEMBL18279731 | 0.84 | TRPV4 (0.34) | TRPV4HRH3CTSKGRIN2B | |
| SCHEMBL18279704 | 0.84 | TRPV4 (0.34) | TRPV4HRH3CTSKGRIN2B | |
| SCHEMBL17008378 | 0.84 | CTSK (0.43) | TBXA2RSMN1; SMN2ALOX5APCTSKHTT | |
| SCHEMBL18279779 | 0.84 | CTSK (0.43) | TBXA2RSMN1; SMN2ALOX5APCTSKHTT | |
| SCHEMBL18279721 | 0.83 | CTSK (0.54) | CTSK | |
| SCHEMBL18279709 | 0.79 | ALOX5AP (0.33) | ALOX5APHTT | |
| SCHEMBL18279727 | 0.79 | TRPV4 (0.33) | TRPV4HRH3GRIN2B | |
| SCHEMBL17008326 | 0.79 | TRPV4 (0.33) | TRPV4HRH3GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3104705-B1 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | MERCK SHARP & DOHME (US) | 2021-11-03 | — | — | EP | disclosed |
| US-9656990-B2 | Cathepsin cysteine protease inhibitors | MERCK SHARP & DOHME CORP. (US) | 2017-05-23 | — | — | US | disclosed |
| US-20160355502-A1 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2016-12-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160355502-A1 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | CTSB, CTSS, CTSZ | HCAR2 3092/4885TRPV4 3428/4885HRH3 1600/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.