Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 7/20 | 0.61 |
| ▸ | HTR7 | P34969 | 7/20 | 0.61 |
| ▸ | DRD3 | P35462 | 7/20 | 0.61 |
| ▸ | DRD2 | P14416 | 6/20 | 0.61 |
| ▸ | HTR2B | P41595 | 6/20 | 0.61 |
| ▸ | HTR2A | P28223 | 5/20 | 0.61 |
| ▸ | HRH1 | P35367 | 5/20 | 0.61 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.61 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.58 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.58 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.58 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.58 |
| ▸ | HTR5A | P47898 | 1/20 | 0.56 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30305062 | 1.00 | HTR1A (0.61) | HTR1AHTR7DRD3DRD2HTR2B | |
| Hydrochloric Acid SCHEMBL22527658 | 0.98 | HTR1A (0.60) | HTR1AHTR7DRD3DRD2HTR2B | |
| Bromide SCHEMBL6523006 | 0.98 | HTR1A (0.60) | HTR1AHTR7DRD3DRD2HTR2B | |
| Hydrochloric Acid SCHEMBL30541930 | 0.98 | HTR1A (0.60) | HTR1AHTR7DRD3DRD2HTR2B | |
| Acetic Acid SCHEMBL6524435 | 0.91 | DRD3 (0.64) | HTR1AHTR7DRD3DRD2HTR2B | |
| SCHEMBL1193409 | 0.89 | HDAC3 (0.59) | HTR1AHTR7DRD3DRD2HTR2B | |
| SCHEMBL30381429 | 0.89 | HDAC3 (0.59) | HTR1AHTR7DRD3DRD2HTR2B | |
| Bromide SCHEMBL6522977 | 0.87 | HDAC3 (0.58) | HTR1AHTR7DRD3DRD2HTR2B | |
| SCHEMBL6526310 | 0.87 | HTR7 (0.65) | HTR1AHTR7DRD3DRD2HTR2B | |
| SCHEMBL9378373 | 0.87 | ALDH1A1 (0.58) | HTR1AHTR7DRD3DRD2HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4491665-A | QUARTERNIZATION, ESTERIFICATION | BURROUGHS WELLCOME CO. (US) | 1985-01-01 | — | — | US | claimed |
| CN-110650950-B | Compounds for the treatment or prophylaxis of PRMT5 mediated diseases | 阿古诺治疗有限公司 | 2023-09-19 | — | — | CN | disclosed |
| EP-3596061-B1 | COMPOUNDS USEFUL IN THE TREATMENT OR PREVENTION OF A PRMT5-MEDIATED DISORDER | ARGONAUT THERAPEUTICS LTD (GB) | 2023-09-06 | — | — | EP | disclosed |
| EP-3498701-B1 | PRMT5 INHIBITORS AND USES THEREOF | EPIZYME INC (US) | 2023-02-22 | — | — | EP | disclosed |
| WO-2021254493-A1 | CYCLIC COMPOUND HAVING ANTI-TUMOR ACTIVITY AND USE THEREOF | 上海翊石医药科技有限公司 | 2021-12-23 | — | — | WO | disclosed |
| US-20200325128-A1 | COMPOUNDS USEFUL IN THE TREATMENT OR PREVENTION OF A PRMT5-MEDIATED DISORDER | Argonaut Therapeutics Limited (GB) | 2020-10-15 | — | — | US | disclosed |
| CN-110650950-A | Compounds for treating or preventing PRMT5 mediated diseases | 阿古诺治疗有限公司 | 2020-01-03 | — | — | CN | disclosed |
| EP-2935243-B1 | PRMT5 INHIBITORS CONTAINING A DIHYDRO- OR TETRAHYDROISOQUINOLINE AND USES THEREOF | EPIZYME INC (US) | 2018-03-14 | — | — | EP | disclosed |
| US-9388173-B2 | PRMT5 inhibitors and uses thereof | Epizyme, Inc. (US) | 2016-07-12 | — | — | US | disclosed |
| US-9365555-B2 | PRMT5 inhibitors and uses thereof | Epizyme, Inc. | 2016-06-14 | — | — | US | disclosed |
| US-20150133427-A1 | PRMT5 INHIBITORS AND USES THEREOF | Epizyme, Inc. (US) | 2015-05-14 | — | — | US | disclosed |
| US-8906900-B2 | PRMT5 inhibitors and uses thereof | Epizyme, Inc. (US) | 2014-12-09 | — | — | US | disclosed |
| US-20140228343-A1 | PRMT5 INHIBITORS AND USES THEREOF | Epizyme, Inc. (US) | 2014-08-14 | — | — | US | disclosed |
| US-20140213582-A1 | PRMT5 INHIBITORS AND USES THEREOF | Epizyme, Inc. (US) | 2014-07-31 | — | — | US | disclosed |
| EP-2315614-A1 | CATIONIC DIHYDROISOQUINOLINIUM DERIVATIVES FOR USE AS BLEACH ACTIVATORS | Henkel AG & Co. KGaA (DE) | 2011-05-04 | — | — | EP | disclosed |
| WO-2010022995-A1 | CATIONIC DIHYDROISOQUINOLINIUM DERIVATIVES FOR USE AS BLEACH ACTIVATORS | HENKEL AG & CO. KGAA (DE) | 2010-03-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150133427-A1 | PRMT5 INHIBITORS AND USES THEREOF | PRMT5, PRMT1, PRMT6 | HTR1A 4598/4885HTR7 4142/4885DRD3 4841/4885 |
| US-20140228343-A1 | PRMT5 INHIBITORS AND USES THEREOF | PRMT5, PRMT1, PRMT6 | HTR1A 4598/4885HTR7 4142/4885DRD3 4841/4885 |
| US-20200325128-A1 | COMPOUNDS USEFUL IN THE TREATMENT OR PREVENTION OF A PRMT5-MEDIATED DISORDER | PRMT5, PRMT6, PRMT1 | HTR1A 4581/4885HTR7 4365/4885DRD3 4695/4885 |
| US-20140213582-A1 | PRMT5 INHIBITORS AND USES THEREOF | PRMT5, PRMT1, PRMT6 | HTR1A 4598/4885HTR7 4142/4885DRD3 4841/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.