Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 3/20 | 0.53 |
| ▸ | CES1 | P23141 | 3/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | SNCA | P37840 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27301248 | 0.83 | SLC6A4 (0.43) | CES2CES1L3MBTL1GAAALDH1A1 | |
| SCHEMBL21807118 | 0.83 | SMN1; SMN2 (0.43) | GAAALDH1A1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL27696670 | 0.83 | DGAT1 (0.53) | L3MBTL1GAAALDH1A1MAPTRAB9A | |
| SCHEMBL3184249 | 0.82 | CES2 (0.68) | CES2CES1L3MBTL1GAAALDH1A1 | |
| SCHEMBL27736558 | 0.81 | AR (0.45) | CES2CES1GAAALDH1A1KDM4E | |
| SCHEMBL25108817 | 0.80 | SMN1; SMN2 (0.46) | GAAMAPTRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL27634442 | 0.80 | KEAP1 (0.36) | CES2CES1ALDH1A1 | |
| SCHEMBL12157631 | 0.79 | ALDH1A1 (0.52) | CES2CES1L3MBTL1GAAALDH1A1 | |
| SCHEMBL14012584 | 0.78 | CES2 (0.61) | CES2CES1L3MBTL1GAAALDH1A1 | |
| SCHEMBL10621241 | 0.78 | CES2 (0.61) | CES2CES1L3MBTL1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240287129-A1 | DECARBOXYLATIVE CONJUGATE ADDITIONS AND APPLICATIONS THEREOF | THE TRUSTEES OF PRINCETON UNIVERSITY | 2024-08-29 | — | — | US | disclosed |
| US-11981704-B2 | Decarboxylative conjugate additions and applications thereof | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 2024-05-14 | — | — | US | disclosed |
| US-20220002342-A1 | DECARBOXYLATIVE CONJUGATE ADDITIONS AND APPLICATIONS THEREOF | THE TRUSTEES OF PRINCETON UNIVERSITY | 2022-01-06 | — | — | US | disclosed |
| US-11136349-B2 | Decarboxylative conjugate additions and applications thereof | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 2021-10-05 | — | — | US | disclosed |
| US-20180179248-A1 | DECARBOXYLATIVE CONJUGATE ADDITIONS AND APPLICATIONS THEREOF | THE TRUSTEES OF PRINCETON UNIVERSITY | 2018-06-28 | — | — | US | disclosed |
| WO-2016196931-A1 | DECARBOXYLATIVE CONJUGATE ADDITIONS AND APPLICATIONS THEREOF | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 2016-12-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180179248-A1 | DECARBOXYLATIVE CONJUGATE ADDITIONS AND APPLICATIONS THEREOF | PTMS, DNPEP, QPCT | CES2 2119/4885CES1 1954/4885L3MBTL1 2802/4885 |
| US-20220002342-A1 | DECARBOXYLATIVE CONJUGATE ADDITIONS AND APPLICATIONS THEREOF | PTMS, DNPEP, QPCT | CES2 2119/4885CES1 1954/4885L3MBTL1 2802/4885 |
| US-20240287129-A1 | DECARBOXYLATIVE CONJUGATE ADDITIONS AND APPLICATIONS THEREOF | PTMS, DNPEP, QPCT | CES2 2119/4885CES1 1954/4885L3MBTL1 2802/4885 |
| US-11981704-B2 | Decarboxylative conjugate additions and applications thereof | PTMS, DNPEP, QPCT | CES2 2119/4885CES1 1954/4885L3MBTL1 2802/4885 |
| US-11136349-B2 | Decarboxylative conjugate additions and applications thereof | PTMS, DNPEP, QPCT | CES2 2119/4885CES1 1954/4885L3MBTL1 2802/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.