Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOD1 | P00441 | 1/20 | 0.45 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.40 |
| ▸ | FDPS | P14324 | 8/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | PTGES | O14684 | 1/20 | 0.35 |
| ▸ | PNLIP | P16233 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | GGPS1 | O95749 | 4/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18290200 | 0.72 | SOD1 (0.76) | SOD1KARS1FDPSMEN1KMT2A | |
| SCHEMBL18290291 | 0.70 | KARS1 (0.47) | SOD1KARS1FDPSMEN1KMT2A | |
| SCHEMBL13532266 | 0.70 | SOD1 (0.52) | SOD1KARS1FDPSMEN1KMT2A | |
| SCHEMBL18290209 | 0.67 | KARS1 (0.50) | SOD1KARS1FDPSMEN1KMT2A | |
| Sugiol SCHEMBL28605319 | 0.66 | SOD1 (0.58) | SOD1KARS1FDPSMEN1KMT2A | |
| Sugiol SCHEMBL17407685 | 0.66 | SOD1 (0.58) | SOD1KARS1FDPSMEN1KMT2A | |
| Sugiol SCHEMBL1086916 | 0.66 | SOD1 (0.58) | SOD1KARS1FDPSMEN1KMT2A | |
| SCHEMBL16006769 | 0.65 | KARS1 (0.43) | SOD1KARS1FDPSMEN1KMT2A | |
| SCHEMBL29934500 | 0.65 | SOD1 (0.52) | SOD1KARS1FDPSMEN1KMT2A | |
| Ferruginol SCHEMBL13423521 | 0.65 | KARS1 (0.73) | KARS1FDPSMEN1KMT2APTGES |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016192631-A1 | ABIETANE-TYPE DITERPENE COMPOUND HAVING LIPID-LOWERING ACTIVITY, METHOD FOR PREPARING SAME, AND USE OF SAME | 中国科学院上海药物研究所 | 2016-12-08 | — | — | WO | disclosed |