Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 2/20 | 0.58 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.52 |
| ▸ | USP2 | O75604 | 2/20 | 0.49 |
| ▸ | FDPS | P14324 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | POLA1 | P09884 | 6/20 | 0.45 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | BCL9 | O00512 | 3/20 | 0.43 |
| ▸ | CTNNB1 | P35222 | 3/20 | 0.43 |
| ▸ | PTGES | O14684 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ferruginol SCHEMBL5315022 | 0.88 | KARS1 (0.73) | KARS1CYP19A1USP2FDPSMEN1 | |
| Ferruginol SCHEMBL13423521 | 0.88 | KARS1 (0.73) | KARS1CYP19A1USP2FDPSMEN1 | |
| Ferruginol SCHEMBL155580 | 0.88 | KARS1 (0.73) | KARS1CYP19A1USP2FDPSMEN1 | |
| Sempervirol SCHEMBL10524412 | 0.83 | KARS1 (0.66) | KARS1CYP19A1USP2FDPSMEN1 | |
| Sempervirol SCHEMBL29495146 | 0.83 | KARS1 (0.66) | KARS1CYP19A1USP2FDPSMEN1 | |
| Sempervirol SCHEMBL10524413 | 0.83 | KARS1 (0.66) | KARS1CYP19A1USP2FDPSMEN1 | |
| SCHEMBL18290300 | 0.81 | POLA1 (0.44) | KARS1CYP19A1USP2FDPSMEN1 | |
| 18-Hydroxyferruginol SCHEMBL18290210 | 0.79 | KARS1 (0.67) | KARS1USP2FDPSMEN1CYP3A4 | |
| 18-Hydroxyferruginol SCHEMBL32666150 | 0.79 | KARS1 (0.67) | KARS1USP2FDPSMEN1CYP3A4 | |
| Pisiferol SCHEMBL30298475 | 0.77 | FDPS (0.70) | KARS1CYP19A1USP2FDPSMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016192631-A1 | ABIETANE-TYPE DITERPENE COMPOUND HAVING LIPID-LOWERING ACTIVITY, METHOD FOR PREPARING SAME, AND USE OF SAME | 中国科学院上海药物研究所 | 2016-12-08 | — | — | WO | disclosed |