Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLA1 | P09884 | 6/20 | 0.44 |
| ▸ | KARS1 | Q15046 | 2/20 | 0.42 |
| ▸ | FDPS | P14324 | 5/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | BCL9 | O00512 | 3/20 | 0.36 |
| ▸ | CTNNB1 | P35222 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | PTGES | O14684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | PNLIP | P16233 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18290306 | 0.84 | KARS1 (0.40) | POLA1KARS1FDPS | |
| SCHEMBL18290298 | 0.81 | KARS1 (0.58) | POLA1KARS1FDPSCYP19A1BCL9 | |
| Hinokiol SCHEMBL18290363 | 0.70 | KARS1 (0.63) | POLA1KARS1FDPSCYP19A1BCL9 | |
| Hinokiol SCHEMBL854936 | 0.70 | KARS1 (0.63) | POLA1KARS1FDPSCYP19A1BCL9 | |
| Pisiferol SCHEMBL30298475 | 0.69 | FDPS (0.70) | KARS1FDPSCYP19A1BCL9CTNNB1 | |
| SCHEMBL7141710 | 0.68 | FDPS (0.43) | POLA1KARS1FDPSBCL9CTNNB1 | |
| Ferruginol SCHEMBL13423521 | 0.68 | KARS1 (0.73) | POLA1KARS1FDPSCYP19A1BCL9 | |
| Ferruginol SCHEMBL5315022 | 0.68 | KARS1 (0.73) | POLA1KARS1FDPSCYP19A1BCL9 | |
| Ferruginol SCHEMBL155580 | 0.68 | KARS1 (0.73) | POLA1KARS1FDPSCYP19A1BCL9 | |
| SCHEMBL14542272 | 0.67 | CYP3A4 (0.65) | POLA1CYP19A1CYP3A4MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016192631-A1 | ABIETANE-TYPE DITERPENE COMPOUND HAVING LIPID-LOWERING ACTIVITY, METHOD FOR PREPARING SAME, AND USE OF SAME | 中国科学院上海药物研究所 | 2016-12-08 | — | — | WO | disclosed |