Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 1/20 | 0.42 |
| ▸ | SOD1 | P00441 | 1/20 | 0.39 |
| ▸ | POLA1 | P09884 | 2/20 | 0.33 |
| ▸ | TYR | P14679 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.30 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16006712 | 0.73 | KARS1 (0.48) | KARS1SOD1POLA1HSP90AA1MAPK1 | |
| SCHEMBL17388698 | 0.73 | KARS1 (0.48) | KARS1SOD1POLA1HSP90AA1MAPK1 | |
| SCHEMBL18290299 | 0.73 | KARS1 (0.48) | KARS1SOD1POLA1HSP90AA1MAPK1 | |
| SCHEMBL18290217 | 0.71 | KARS1 (0.47) | KARS1SOD1POLA1HSP90AA1MAPK1 | |
| SCHEMBL18290297 | 0.71 | KARS1 (0.47) | KARS1SOD1POLA1HSP90AA1MAPK1 | |
| SCHEMBL17403057 | 0.70 | CACNA1G (0.44) | KARS1SOD1CYP1A2CYP2D6MAPK1 | |
| SCHEMBL3186292 | 0.70 | SOD1 (0.43) | KARS1SOD1HSP90AA1CYP1A2CYP2D6 | |
| SCHEMBL29973971 | 0.68 | TYR (0.53) | TYRHSP90AA1HSP90AB1CYP1A2CYP2D6 | |
| SCHEMBL723126 | 0.68 | TYR (0.53) | TYRHSP90AA1HSP90AB1CYP1A2CYP2D6 | |
| SCHEMBL8014515 | 0.66 | RXRA (0.49) | KARS1SOD1CYP1A2CYP2D6LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016192631-A1 | ABIETANE-TYPE DITERPENE COMPOUND HAVING LIPID-LOWERING ACTIVITY, METHOD FOR PREPARING SAME, AND USE OF SAME | 中国科学院上海药物研究所 | 2016-12-08 | — | — | WO | disclosed |