Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOD1 | P00441 | 1/20 | 0.41 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.32 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.32 |
| ▸ | TOP2A | P11388 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | GGPS1 | O95749 | 1/20 | 0.30 |
| ▸ | FDPS | P14324 | 1/20 | 0.30 |
| ▸ | AR | P10275 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18290214 | 0.84 | RXRA (0.32) | SOD1MAPT | |
| SCHEMBL17403057 | 0.80 | CACNA1G (0.44) | SOD1KARS1CYP3A4LMNATP53 | |
| SCHEMBL18290213 | 0.77 | SOD1 (0.41) | SOD1KARS1CYP3A4LMNATP53 | |
| SCHEMBL18290200 | 0.64 | SOD1 (0.76) | SOD1KARS1HSP90AA1CYP3A4TP53 | |
| SCHEMBL18290372 | 0.63 | SOD1 (0.65) | SOD1KARS1CYP3A4LMNATP53 | |
| SCHEMBL3186292 | 0.63 | SOD1 (0.43) | SOD1KARS1HSP90AA1CYP3A4LMNA | |
| Sugiol SCHEMBL17407685 | 0.62 | SOD1 (0.58) | SOD1KARS1HSP90AA1CYP3A4TP53 | |
| SCHEMBL18290356 | 0.62 | SOD1 (0.38) | SOD1KARS1HSP90AA1CYP3A4LMNA | |
| Hypargenin C SCHEMBL18290364 | 0.62 | SOD1 (0.55) | SOD1KARS1HSP90AA1CYP3A4TP53 | |
| Hypargenin C SCHEMBL13532268 | 0.62 | SOD1 (0.55) | SOD1KARS1HSP90AA1CYP3A4TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016192631-A1 | ABIETANE-TYPE DITERPENE COMPOUND HAVING LIPID-LOWERING ACTIVITY, METHOD FOR PREPARING SAME, AND USE OF SAME | 中国科学院上海药物研究所 | 2016-12-08 | — | — | WO | disclosed |