Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23362516 | 0.81 | ABL1 (0.33) | ABL1PIK3CDKDM4EALDH1A1POLB | |
| SCHEMBL15900497 | 0.78 | KDM4E (0.37) | PIK3CDKDM4EALDH1A1POLB | |
| SCHEMBL186339 | 0.74 | EGLN2 (0.42) | ABL1PIK3CDKDM4EALDH1A1POLB | |
| SCHEMBL29929823 | 0.74 | EGLN2 (0.42) | ABL1PIK3CDKDM4EALDH1A1POLB | |
| SCHEMBL384105 | 0.71 | KEAP1 (0.38) | ABL1PIK3CDKDM4EALDH1A1POLB | |
| SCHEMBL18109302 | 0.71 | PIK3CD (0.51) | ABL1PIK3CDKDM4EALDH1A1POLB | |
| SCHEMBL16321670 | 0.71 | ALDH1A1 (0.44) | ABL1PIK3CDKDM4EALDH1A1POLB | |
| SCHEMBL2123346 | 0.71 | MAP4K4 (0.31) | — | |
| SCHEMBL1976471 | 0.71 | ABL1 (0.35) | ABL1PIK3CDKDM4EALDH1A1POLB | |
| SCHEMBL30834616 | 0.71 | PIK3CD (0.51) | ABL1PIK3CDKDM4EALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016196776-A2 | INHIBITORS OF BRUTON'S TYROSINE KINASE | PHARMACYCLICS LLC. (US) | 2016-12-08 | — | — | WO | disclosed |