Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KAT6A | Q92794 | 2/20 | 0.61 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.60 |
| ▸ | EP300 | Q09472 | 2/20 | 0.52 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.52 |
| ▸ | BAZ2B | Q9UIF8 | 2/20 | 0.52 |
| ▸ | RXRA | P19793 | 1/20 | 0.51 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.50 |
| ▸ | ERN1 | O75460 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18311307 | 0.87 | KAT6A (0.57) | KAT6AKEAP1EP300CREBBPBAZ2B | |
| SCHEMBL5924902 | 0.85 | KEAP1 (0.74) | KAT6AKEAP1EP300CREBBPBAZ2B | |
| SCHEMBL31151058 | 0.85 | KEAP1 (0.74) | KAT6AKEAP1EP300CREBBPBAZ2B | |
| SCHEMBL2385998 | 0.82 | ALDH1A1 (0.53) | KAT6AERN1ALDH1A1KDM4EMEN1 | |
| SCHEMBL18304663 | 0.81 | KEAP1 (0.64) | KAT6AKEAP1EP300CREBBPBAZ2B | |
| SCHEMBL14150399 | 0.79 | RXRA (0.69) | RXRAMEN1KMT2APOLBNPC1 | |
| SCHEMBL30420728 | 0.79 | RXRA (0.69) | RXRAMEN1KMT2APOLBNPC1 | |
| SCHEMBL18304656 | 0.78 | KEAP1 (0.64) | KAT6AKEAP1EP300CREBBPBAZ2B | |
| SCHEMBL18304658 | 0.78 | KEAP1 (0.64) | KAT6AKEAP1EP300CREBBPBAZ2B | |
| SCHEMBL2723466 | 0.78 | KEAP1 (0.64) | KAT6AKEAP1EP300CREBBPBAZ2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3307258-B1 | ARYL SULFONOHYDRAZIDES | UNIV MONASH (AU) | 2020-12-16 | — | — | EP | disclosed |
| EP-3307258-B1 | ARYL SULFONOHYDRAZIDES | UNIV MONASH (AU) | 2020-12-16 | — | — | EP | disclosed |
| US-10829446-B2 | Aryl sulfonohydrazides | MONASH UNIVERSITY (AU) | 2020-11-10 | — | — | US | disclosed |
| US-10829446-B2 | Aryl sulfonohydrazides | MONASH UNIVERSITY (AU) | 2020-11-10 | — | — | US | disclosed |
| US-20180222857-A1 | ARYL SULFONOHYDRAZIDES | MONASH UNIVERSITY (AU) | 2018-08-09 | — | — | US | disclosed |
| US-20180222857-A1 | ARYL SULFONOHYDRAZIDES | MONASH UNIVERSITY (AU) | 2018-08-09 | — | — | US | disclosed |
| US-20180222857-A1 | ARYL SULFONOHYDRAZIDES | MONASH UNIVERSITY (AU) | 2018-08-09 | — | — | US | disclosed |
| EP-3307258-A1 | ARYL SULFONOHYDRAZIDES | Monash University (AU) | 2018-04-18 | — | — | EP | disclosed |
| WO-2016198507-A1 | ARYL SULFONOHYDRAZIDES | MONASH UNIVERSITY (AU) | 2016-12-15 | — | — | WO | disclosed |
| WO-2016198507-A1 | ARYL SULFONOHYDRAZIDES | MONASH UNIVERSITY (AU) | 2016-12-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180222857-A1 | ARYL SULFONOHYDRAZIDES | FPR3, NCOA3, HAT1 | KAT6A 130/4885KEAP1 2018/4885EP300 51/4885 |
| US-10829446-B2 | Aryl sulfonohydrazides | FPR3, NCOA3, HAT1 | KAT6A 130/4885KEAP1 2018/4885EP300 51/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.