Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 4/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.35 |
| ▸ | LIMK1 | P53667 | 3/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.34 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.33 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.33 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.32 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.32 |
| ▸ | LCK | P06239 | 1/20 | 0.32 |
| ▸ | FYN | P06241 | 1/20 | 0.32 |
| ▸ | CSF1R | P07333 | 1/20 | 0.32 |
| ▸ | LYN | P07948 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18306350 | 0.84 | TGFBR1 (0.39) | ABL1ROCK1TGFBR1TGFBR2FGFR1 | |
| SCHEMBL19661563 | 0.82 | MEN1 (0.40) | ABL1ROCK2LIMK1LCKFYN | |
| SCHEMBL19654959 | 0.76 | TGFBR1 (0.40) | ROCK2LIMK1ROCK1TGFBR1GSK3B | |
| SCHEMBL16473243 | 0.75 | KMT2A (0.39) | ABL1TGFBR1TGFBR2GSK3BMAPK14 | |
| SCHEMBL15639059 | 0.73 | ABL1 (0.43) | ABL1GSK3BMAPK14GAASLC9A1 | |
| SCHEMBL15638351 | 0.72 | ROCK1 (0.52) | ABL1ROCK2ROCK1TGFBR1MAPK14 | |
| SCHEMBL16473244 | 0.69 | TGFBR1 (0.50) | ABL1TGFBR1TGFBR2MAPK14LRRK2 | |
| SCHEMBL17177325 | 0.69 | ABL1 (0.36) | ABL1ROCK1FGFR1GSK3BLRRK2 | |
| SCHEMBL15638185 | 0.69 | TGFBR1 (0.42) | ABL1ROCK1TGFBR1FGFR1FGFR2 | |
| SCHEMBL18306360 | 0.67 | IRAK4 (0.35) | ROCK1FGFR1GSK3BMAPK14LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170342048-A1 | GDF-8 Inhibitors | MIDCAP FINANCIAL TRUST | 2017-11-30 | — | — | US | disclosed |
| US-9518040-B2 | GDF-8 inhibitors | RIGEL PHARMACEUTICALS, INC. (US) | 2016-12-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170342048-A1 | GDF-8 Inhibitors | MSTN, MYOF, CXCL8 | ABL1 2930/4885ROCK2 500/4885LIMK1 2870/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.