Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 2/20 | 0.40 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.38 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.38 |
| ▸ | KDR | P35968 | 5/20 | 0.38 |
| ▸ | LCK | P06239 | 3/20 | 0.38 |
| ▸ | FLT4 | P35916 | 3/20 | 0.38 |
| ▸ | FLT3 | P36888 | 3/20 | 0.38 |
| ▸ | BLK | P51451 | 3/20 | 0.38 |
| ▸ | FYN | P06241 | 2/20 | 0.38 |
| ▸ | CSF1R | P07333 | 2/20 | 0.38 |
| ▸ | LYN | P07948 | 2/20 | 0.38 |
| ▸ | KIT | P10721 | 2/20 | 0.38 |
| ▸ | SRC | P12931 | 2/20 | 0.38 |
| ▸ | P2RY1 | P47900 | 3/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | FLT1 | P17948 | 2/20 | 0.37 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18306358 | 0.88 | TGFBR1 (0.42) | TGFBR1GRM4MAPK14MAPK13MAPK12 | |
| SCHEMBL18306371 | 0.86 | TGFBR1 (0.40) | TGFBR1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL19817527 | 0.84 | KMT2A (0.44) | TGFBR1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL21317812 | 0.82 | TGFBR1 (0.36) | TGFBR1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL17177376 | 0.82 | TGFBR1 (0.44) | TGFBR1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL18306375 | 0.81 | TGFBR1 (0.38) | TGFBR1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL21317808 | 0.79 | DHODH (0.40) | TGFBR1 | |
| SCHEMBL17177475 | 0.79 | CHRNA7 (0.35) | TGFBR1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL19661563 | 0.77 | MEN1 (0.40) | KDRLCKFLT4FLT3BLK | |
| SCHEMBL18306364 | 0.76 | ABL1 (0.40) | TGFBR1MAPK14KDRLCKFLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170342048-A1 | GDF-8 Inhibitors | MIDCAP FINANCIAL TRUST | 2017-11-30 | — | — | US | disclosed |
| US-20170342048-A1 | GDF-8 Inhibitors | MIDCAP FINANCIAL TRUST | 2017-11-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170342048-A1 | GDF-8 Inhibitors | MSTN, MYOF, CXCL8 | TGFBR1 128/4885GRM4 1613/4885MAPK14 2533/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.