Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 5/20 | 0.50 |
| ▸ | ABL1 | P00519 | 1/20 | 0.49 |
| ▸ | NQO2 | P16083 | 6/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | GLA | P06280 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | CFTR | P13569 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9793695 | 0.83 | GAA (0.59) | GAAABL1NQO2KDM4EALDH1A1 | |
| SCHEMBL31056006 | 0.82 | ERN1 (0.48) | GAAABL1KDM4EALDH1A1MAPT | |
| SCHEMBL31056011 | 0.82 | ERN1 (0.48) | GAAABL1KDM4EALDH1A1MAPT | |
| SCHEMBL7762378 | 0.81 | ABL1 (0.61) | GAAABL1NQO2KDM4EALDH1A1 | |
| SCHEMBL19328721 | 0.81 | GAA (0.72) | GAAABL1NQO2KDM4EALDH1A1 | |
| SCHEMBL17632541 | 0.81 | ALDH1A1 (0.50) | GAAKDM4EALDH1A1HSD17B10GLA | |
| SCHEMBL15823317 | 0.79 | GAA (0.46) | GAAABL1NQO2KDM4EALDH1A1 | |
| SCHEMBL15823315 | 0.79 | GAA (0.46) | GAAABL1NQO2KDM4EALDH1A1 | |
| SCHEMBL23774898 | 0.78 | GAA (0.54) | GAAABL1NQO2KDM4EALDH1A1 | |
| SCHEMBL2897626 | 0.78 | GAA (0.62) | GAAABL1NQO2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230159510-A1 | NOVEL PRMT5 INHIBITORS | AMGEN INC. (US) | 2023-05-25 | — | — | US | disclosed |
| US-20230159510-A1 | NOVEL PRMT5 INHIBITORS | AMGEN INC. (US) | 2023-05-25 | — | — | US | disclosed |
| EP-4103558-A1 | NOVEL PRMT5 INHIBITORS | Amgen Inc. (US) | 2022-12-21 | — | — | EP | disclosed |
| WO-2021163344-A1 | NOVEL PRMT5 INHIBITORS | AMGEN INC. (US) | 2021-08-19 | — | — | WO | disclosed |
| WO-2021163344-A1 | NOVEL PRMT5 INHIBITORS | AMGEN INC. (US) | 2021-08-19 | — | — | WO | disclosed |
| EP-3307730-B1 | HERBICIDAL COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2019-07-24 | — | — | EP | disclosed |
| US-10194660-B2 | Herbicidal compounds | SYNGENTA PARTICIPATIONS AG (CH) | 2019-02-05 | — | — | US | disclosed |
| US-20180177190-A1 | HERBICIDAL COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2018-06-28 | — | — | US | disclosed |
| WO-2016198585-A1 | HERBICIDAL COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2016-12-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180177190-A1 | HERBICIDAL COMPOUNDS | DDT, CYP1B1, ATP1B1 | GAA 295/4885ABL1 1304/4885NQO2 97/4885 |
| US-20230159510-A1 | NOVEL PRMT5 INHIBITORS | PRMT5, PRMT1, PRMT3 | GAA 3863/4885ABL1 432/4885NQO2 1214/4885 |
| US-10194660-B2 | Herbicidal compounds | DDT, CYP1B1, ATP1B1 | GAA 295/4885ABL1 1304/4885NQO2 97/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.