SCHEMBL523465

SCHEMBL523465

Nc1nc2c(ncn2-n2cnc3cncnc32)c(=O)[nH]1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
XDH P47989 8/20 0.47
PNP P00491 4/20 0.44
TK1 P04183 2/20 0.44
BLM P54132 2/20 0.43
USP2 O75604 1/20 0.43
TSHR P16473 1/20 0.43
EDNRA P25101 1/20 0.43
HTR2A P28223 1/20 0.43
RECQL P46063 1/20 0.43
HBB P68871 1/20 0.43
HSD17B10 Q99714 1/20 0.43
MEN1 O00255 2/20 0.42
KMT2A Q03164 2/20 0.42
ALDH1A1 P00352 1/20 0.42
LMNA P02545 1/20 0.42
CYP3A4 P08684 1/20 0.42
NFKB1 P19838 1/20 0.42
VCP P55072 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
HIF1A Q16665 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28695644 0.85 XDH (0.43) XDHPNPTK1BLMUSP2
SCHEMBL986800 0.84 XDH (0.60) XDHPNPTK1BLMUSP2
SCHEMBL5607948 0.84 XDH (0.31) XDHALDH1A1
SCHEMBL3953063 0.84 XDH (0.38) XDHPNPTK1BLMUSP2
SCHEMBL15005119 0.83 XDH (0.59) XDHPNPTK1BLMUSP2
SCHEMBL4899457 0.81 XDH (0.44) XDHPNPTK1BLMUSP2
SCHEMBL27594330 0.80 HPRT1 (0.42) XDHPNPTK1BLMUSP2
SCHEMBL1831279 0.80 XDH (0.50) XDHPNPTK1BLMUSP2
SCHEMBL1426626 0.77 FDPS (0.34) PNPUSP2TSHRHBBMEN1
SCHEMBL8421362 0.77 TK1 (0.31) XDHTK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 217 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023241051-A1 FLUORESCENTLY LABELED COMPOSITE SGRNA, AND PREPARATION METHOD THEREFOR AND USE THEREOF 图维生物医药科技(苏州)有限公司 2023-12-21 WO claimed
US-20240226275-A1 COMPOSITIONS AND METHODS OF MRNA VACCINES AGAINST NOVEL CORONAVIRUS INFECTION RNAimmune, Inc. (US) 2024-07-11 US disclosed
CN-118302181-A Multigang TP53 and PAN-RAS mRNA cancer vaccine 达冕生物有限公司 2024-07-05 CN disclosed
EP-4388017-A1 COMPOSITIONS AND METHODS FOR ANTI-VIRUS CHIMERIC ANTIGEN RECEPTOR Rudd, Christopher E. (CA) 2024-06-26 EP disclosed
EP-4384214-A2 COMPOSITION AND METHODS OF MRNA VACCINES AGAINST NOVEL CORONAVIRUS INFECTION Rnaimmune, Inc. (US) 2024-06-19 EP disclosed
CN-118119930-A Compositions and methods for mRNA vaccines against novel coronavirus infection 达冕生物有限公司 2024-05-31 CN disclosed
US-20240156947-A1 COMPOSITION AND METHODS FOR MRNA VACCINES AGAINST NOVEL OMICRON CORONAVIRUS INFECTIONS RNAimmune, Inc. (US) 2024-05-16 US disclosed
WO-2024097259-A1 COMPOSITION AND METHODS FOR MRNA VACCINES AGAINST NOVEL OMICRON CORONAVIRUS INFECTIONS RNAimmune, Inc. (US) 2024-05-10 WO disclosed
WO-2024097894-A1 COMPOSITIONS AND METHODS OF RIBONUCLEIC ACID VACCINES ENCODING NYE-SO-1 RNAimmune, Inc. (US) 2024-05-10 WO disclosed
EP-4351615-A2 MULTIPLEXED TP53 AND PAN-RAS MRNA CANCER VACCINES Rnaimmune, Inc. (US) 2024-04-17 EP disclosed
EP-0472498-A1 Monoclonal antibodies to leptosphaeria CIBA-GEIGY AG (CH) 1992-02-26 EP disclosed
EP-0465415-A2 Monoclonal antibodies to mycosphaerella species CIBA-GEIGY AG (CH) 1992-01-08 EP disclosed
US-4879217-A MONOCLONAL ANTIBODIES FOR IMMUNOASSAY AGRI-DIAGNOSTICS ASSOCIATES (US) 1989-11-07 US disclosed
US-4845197-A IMMUNOLOGICAL DETECTION OF FUNGAL PLANT DISEASES AGRI-DIAGNOSTICS ASSOCIATES (US) 1989-07-04 US disclosed
US-4803155-A DETECTION OF PATHOGENIC FUNGUS IN TURFGRASS, USING AN ANALYTICALLY DETECTABLE LABELLED ANTIBODY-ANTIGEN COMPLEX AGRI-DIAGNOSTICS ASSOCIATES (US) 1989-02-07 US disclosed
EP-0292719-A2 A test for rhizoctonia brown and yellow patch DNAP DIAGNOSTICS, INC. (a Delaware corporation) (US) 1988-11-30 EP disclosed
EP-0234501-A2 Monocional antibodies and methods for fungal pathogen detection DNAP DIAGNOSTICS, INC. (a Delaware corporation) (US) 1987-09-02 EP disclosed
EP-0222998-A2 Monoclonal antibodies and methods for fungal pathogen detection DNAP DIAGNOSTICS, INC. (a Delaware corporation) (US) 1987-05-27 EP disclosed
US-4564597-A Anti-Sm hybridoma RESEARCH CORPORATION (US) 1986-01-14 US disclosed
US-4246408-A Imidazo[1,2-a]-s-triazine ICN PHARMACEUTICALS (US) 1981-01-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240156947-A1 COMPOSITION AND METHODS FOR MRNA VACCINES AGAINST NOVEL OMICRON CORONAVIRUS INFECTIONS RBM22, RNGTT, RBM25 XDH 4723/4885PNP 200/4885TK1 4555/4885
US-20240226275-A1 COMPOSITIONS AND METHODS OF MRNA VACCINES AGAINST NOVEL CORONAVIRUS INFECTION RNGTT, SARS1, ACE2 XDH 4757/4885PNP 241/4885TK1 4026/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.