Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | GAA | P10253 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.33 |
| ▸ | APEX1 | P27695 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | APP | P05067 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.31 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18319088 | 0.82 | EPHX2 (0.42) | ALDH1A1KDM4EGAASMN1; SMN2L3MBTL1 | |
| SCHEMBL26656819 | 0.79 | DPP4 (0.43) | SMN1; SMN2LMNATSHROPRD1OPRK1 | |
| SCHEMBL27189622 | 0.76 | OPRM1 (0.34) | POLBOPRM1 | |
| SCHEMBL18319504 | 0.75 | ALDH1A1 (0.37) | ALDH1A1GAASMN1; SMN2L3MBTL1 | |
| SCHEMBL4556747 | 0.74 | MEN1 (0.43) | ALDH1A1MAPTLMNARECQLPOLB | |
| SCHEMBL18319195 | 0.73 | KDM4E (0.34) | ALDH1A1KDM4EGAAL3MBTL1POLB | |
| SCHEMBL18319194 | 0.73 | KDM4E (0.34) | ALDH1A1KDM4EGAAL3MBTL1POLB | |
| SCHEMBL2127217 | 0.73 | — | — | |
| SCHEMBL9993508 | 0.70 | HSD11B1 (0.40) | ALDH1A1KDM4EGAASMN1; SMN2L3MBTL1 | |
| SCHEMBL4551724 | 0.69 | OPRM1 (0.42) | ALDH1A1SMN1; SMN2L3MBTL1TSHRPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9920056-B2 | 2-oxo-1,3,8-triazaspiro[4.5]decan-3-yl] carboxylic acid derivatives | ELI LILLY AND COMPANY (US) | 2018-03-20 | — | — | US | disclosed |
| US-20160368922-A1 | 2-OXO-1,3,8-TRIAZASPIRO[4.5]DECAN-3-YL] CARBOXYLIC ACID DERIVATIVES | ELI LILLY AND COMPANY | 2016-12-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160368922-A1 | 2-OXO-1,3,8-TRIAZASPIRO[4.5]DECAN-3-YL] CARBOXYLIC ACID DERIVATIVES | SLC5A2, SLC5A1, GPR119 | ALDH1A1 131/4885KDM4E 1878/4885MAPT 3461/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.