Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | APOBEC3A | P31941 | 2/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.36 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1827955 | 0.87 | NPC1 (0.43) | NPC1RAB9AAPOBEC3ACNR1ALDH1A1 | |
| SCHEMBL5219663 | 0.86 | APOBEC3A (0.52) | NPC1RAB9AAPOBEC3ACNR1ALDH1A1 | |
| SCHEMBL22372020 | 0.74 | SCN9A (0.36) | — | |
| SCHEMBL3013035 | 0.71 | MALT1 (0.33) | ALDH1A1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL1831966 | 0.69 | NPC1 (0.46) | NPC1RAB9AKMT2AMEN1L3MBTL1 | |
| SCHEMBL22372214 | 0.67 | TRPM8 (0.35) | — | |
| SCHEMBL6966618 | 0.67 | ALDH1A1 (0.47) | NPC1RAB9AALDH1A1HTTPOLB | |
| SCHEMBL5806556 | 0.66 | MLYCD (0.34) | RAB9AKMT2AMEN1 | |
| SCHEMBL6969688 | 0.66 | ALDH1A1 (0.46) | NPC1RAB9AALDH1A1HTTKMT2A | |
| SCHEMBL3010551 | 0.65 | TP53 (0.44) | ALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2318375-A1 | IMIDAZOLE CARBOXAMIDES | ELI LILLY AND COMPANY (US) | 2011-05-11 | — | — | EP | disclosed |
| WO-2010009062-A1 | IMIDAZOLE CARBOXAMIDES | ELI LILLY AND COMPANY (US) | 2010-01-21 | — | — | WO | disclosed |