Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | PDE4A | P27815 | 2/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 6/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 6/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.43 |
| ▸ | USP2 | O75604 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CFTR | P13569 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18319731 | 0.78 | L3MBTL1 (0.45) | ALDH1A1SMN1; SMN2LMNAPOLBCYP1A2 | |
| SCHEMBL14472561 | 0.72 | ALDH1A1 (0.50) | ALDH1A1SMN1; SMN2LMNARAB9ARECQL | |
| SCHEMBL5293593 | 0.71 | PDE5A (0.41) | ALDH1A1POLBCYP1A2CYP2C9CYP3A4 | |
| SCHEMBL18319408 | 0.70 | APLNR (0.35) | SMN1; SMN2MEN1KMT2A | |
| SCHEMBL12895971 | 0.68 | ALDH1A1 (0.58) | ALDH1A1SMN1; SMN2LMNARAB9ARECQL | |
| SCHEMBL18319512 | 0.68 | APLNR (0.38) | — | |
| SCHEMBL644097 | 0.67 | ALDH1A1 (0.59) | ALDH1A1SMN1; SMN2LMNARAB9ARECQL | |
| SCHEMBL9700338 | 0.67 | RAB9A (0.40) | ALDH1A1SMN1; SMN2LMNARAB9APDE4D | |
| SCHEMBL5545639 | 0.66 | KDM4E (0.67) | ALDH1A1SMN1; SMN2LMNARAB9APDE4A | |
| SCHEMBL9952997 | 0.66 | ALDH1A1 (0.55) | ALDH1A1SMN1; SMN2LMNARAB9ARECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160368919-A1 | NOVEL PYRIDINE PYRAZINONES AS BET-FAMILY BROMODOMAIN INHIBITORS | PFIZER INC. (US) | 2016-12-22 | — | — | US | disclosed |
| US-20160368919-A1 | NOVEL PYRIDINE PYRAZINONES AS BET-FAMILY BROMODOMAIN INHIBITORS | PFIZER INC. (US) | 2016-12-22 | — | — | US | disclosed |
| WO-2016203335-A1 | NOVEL PYRIDO[2,3-B]PYRAZINONES AS BET-FAMILY BROMODOMAIN INHIBITORS | PFIZER INC. (US) | 2016-12-22 | — | — | WO | disclosed |
| US-20160368919-A1 | NOVEL PYRIDINE PYRAZINONES AS BET-FAMILY BROMODOMAIN INHIBITORS | PFIZER INC. (US) | 2016-12-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160368919-A1 | NOVEL PYRIDINE PYRAZINONES AS BET-FAMILY BROMODOMAIN INHIBITORS | BRD4, BRD3, BET1 | ALDH1A1 3909/4885SMN1; SMN2 4137/4885LMNA 2907/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.