Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 6/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 7/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1834304 | 0.83 | PKM (0.36) | PKMKDM4EALDH1A1MAPTGAA | |
| SCHEMBL317703 | 0.79 | KEAP1 (0.43) | KDM4EALDH1A1KEAP1HTR7GAA | |
| SCHEMBL31653832 | 0.79 | KEAP1 (0.43) | KDM4EALDH1A1KEAP1HTR7GAA | |
| SCHEMBL29549481 | 0.71 | SCN2A (0.54) | KDM4EALDH1A1KEAP1GAALMNA | |
| SCHEMBL3825337 | 0.70 | GAA (0.50) | KDM4EALDH1A1KEAP1MAPTGAA | |
| SCHEMBL3830992 | 0.68 | KEAP1 (0.41) | KDM4EALDH1A1KEAP1MAPTGAA | |
| SCHEMBL3824501 | 0.68 | GAA (0.55) | PKMKDM4EALDH1A1GAALMNA | |
| SCHEMBL4432960 | 0.67 | PTPN1 (0.38) | PKMKDM4EALDH1A1MAPTGAA | |
| SCHEMBL28946278 | 0.66 | ALDH1A1 (0.49) | KDM4EALDH1A1KEAP1MAPTGAA | |
| SCHEMBL17119924 | 0.66 | F2RL1 (0.46) | KEAP1KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2318366-A2 | PSMA-BINDING AGENTS AND USES THEREOF | The Johns Hopkins University (US) | 2011-05-11 | — | — | EP | disclosed |
| WO-2010014933-A2 | PSMA-BINDING AGENTS AND USES THEREOF | THE JOHNS HOPKINS UNIVERSITY (US) | 2010-02-04 | — | — | WO | disclosed |