Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOD1 | Q9Y239 | 5/20 | 0.47 |
| ▸ | NOD2 | Q9HC29 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 6/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | CISD2 | Q8N5K1 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18331706 | 0.85 | NOD1 (0.41) | NOD1NOD2LMNATSHRKDM4E | |
| SCHEMBL18331337 | 0.84 | ALOX5 (0.38) | NOD1NOD2LMNATSHRKDM4E | |
| SCHEMBL18331914 | 0.84 | NOD1 (0.53) | NOD1NOD2LMNATSHRKDM4E | |
| SCHEMBL18332144 | 0.83 | NOD2 (0.56) | NOD1NOD2LMNATSHRKDM4E | |
| SCHEMBL18331404 | 0.82 | ALOX5 (0.37) | NOD1NOD2LMNATSHRKDM4E | |
| SCHEMBL18331336 | 0.81 | ALOX5 (0.36) | NOD1NOD2LMNATSHRKDM4E | |
| SCHEMBL18332251 | 0.81 | ALOX5 (0.36) | NOD1NOD2LMNATSHRKDM4E | |
| SCHEMBL10002626 | 0.80 | NOD1 (0.61) | NOD1NOD2LMNATSHRKDM4E | |
| SCHEMBL18331912 | 0.80 | NOD1 (0.53) | NOD1NOD2LMNATSHRKDM4E | |
| SCHEMBL18331707 | 0.80 | NOD1 (0.53) | NOD1NOD2LMNATSHRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10479780-B2 | Aminopyrazole derivatives | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2019-11-19 | — | — | US | disclosed |
| US-20180362509-A1 | AMINOPYRAZOLE DERIVATIVES | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2018-12-20 | — | — | US | disclosed |
| WO-2016204261-A1 | AMINOPYRAZOLE DERIVATIVES | 中外製薬株式会社 | 2016-12-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10479780-B2 | Aminopyrazole derivatives | SRC, GRK2, GRK3 | NOD1 2710/4885NOD2 2986/4885LMNA 4871/4885 |
| US-20180362509-A1 | AMINOPYRAZOLE DERIVATIVES | SRC, GRK2, GRK3 | NOD1 2710/4885NOD2 2986/4885LMNA 4871/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.