Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | CASP1 | P29466 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20084038 | 0.79 | L3MBTL1 (0.39) | L3MBTL1ALDH1A1CASP1CYP3A4TSHR | |
| SCHEMBL9370034 | 0.79 | CYP3A4 (0.45) | L3MBTL1ALDH1A1CASP1CYP3A4TSHR | |
| SCHEMBL11495612 | 0.74 | TSHR (0.42) | L3MBTL1ALDH1A1CASP1CYP3A4TSHR | |
| SCHEMBL14367967 | 0.73 | PTPN1 (0.44) | ALDH1A1CYP3A4KDM4EMAPTMAPK1 | |
| SCHEMBL13514315 | 0.73 | CYP19A1 (0.46) | L3MBTL1ALDH1A1CYP3A4TSHRCYP19A1 | |
| SCHEMBL865227 | 0.73 | ALDH1A1 (0.54) | L3MBTL1ALDH1A1CASP1CYP3A4TSHR | |
| SCHEMBL15958221 | 0.72 | L3MBTL1 (0.52) | L3MBTL1ALDH1A1CASP1CYP3A4TSHR | |
| SCHEMBL594453 | 0.72 | ALDH1A1 (0.55) | L3MBTL1ALDH1A1CYP3A4TSHRCYP19A1 | |
| SCHEMBL18509676 | 0.69 | ALDH1A1 (0.50) | L3MBTL1ALDH1A1CASP1CYP3A4TSHR | |
| SCHEMBL1406184 | 0.69 | L3MBTL1 (0.70) | L3MBTL1ALDH1A1CASP1CYP3A4TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3312172-B1 | AMINOPYRAZOLE DERIVATIVES USEFUL AS SRC KINASE INHIBITORS | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2020-05-06 | — | — | EP | disclosed |
| EP-3312172-A1 | AMINOPYRAZOLE DERIVATIVES | Chugai Seiyaku Kabushiki Kaisha (JP) | 2018-04-25 | — | — | EP | disclosed |
| WO-2016204261-A1 | AMINOPYRAZOLE DERIVATIVES | 中外製薬株式会社 | 2016-12-22 | — | — | WO | disclosed |