Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.54 |
| ▸ | PDE2A | O00408 | 1/20 | 0.54 |
| ▸ | PDE5A | O76074 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
| ▸ | APEX1 | P27695 | 1/20 | 0.54 |
| ▸ | PDE4A | P27815 | 1/20 | 0.54 |
| ▸ | BLM | P54132 | 1/20 | 0.54 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.54 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.54 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.54 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.54 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.54 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.54 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | CYP19A1 | P11511 | 6/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30204314 | 0.82 | CYP19A1 (0.45) | ALDH1A1TDP1TSHRCYP3A4PDE2A | |
| SCHEMBL9022132 | 0.82 | HSD17B10 (0.53) | ALDH1A1CYP3A4PDE2APDE5AALOX15 | |
| SCHEMBL1131658 | 0.79 | ALDH1A1 (0.62) | ALDH1A1TDP1TSHRCYP3A4PDE2A | |
| SCHEMBL2122702 | 0.79 | CYP19A1 (0.48) | ALDH1A1CYP3A4PDE2APDE5AALOX15 | |
| SCHEMBL2056577 | 0.77 | ALDH1A1 (0.60) | ALDH1A1TDP1TSHRCYP3A4PDE2A | |
| SCHEMBL13514349 | 0.76 | CYP19A1 (0.56) | ALDH1A1TDP1CYP19A1HTT | |
| SCHEMBL13297777 | 0.75 | CYP19A1 (0.62) | ALDH1A1TDP1TSHRCYP3A4PDE2A | |
| SCHEMBL2650351 | 0.74 | ALDH1A1 (0.68) | ALDH1A1TDP1TSHRCYP3A4PDE2A | |
| SCHEMBL35583854 | 0.74 | ALDH1A1 (0.68) | ALDH1A1TDP1TSHRCYP3A4PDE2A | |
| SCHEMBL4245109 | 0.73 | CA1 (0.50) | ALDH1A1TDP1TSHRCYP3A4L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024026500-A2 | INHIBITORS OF PDE11A4 AND METHODS OF USING SAME | UNIVERSITY OF MARYLAND, BALTIMORE (US) | 2024-02-01 | — | — | WO | disclosed |
| WO-2016204261-A1 | AMINOPYRAZOLE DERIVATIVES | 中外製薬株式会社 | 2016-12-22 | — | — | WO | disclosed |
| US-20140128399-A1 | METHODS AND COMPOSITIONS FOR TREATING URINARY TRACT INFECTIONS USING AGENTS THAT MIMIC OR ELEVATE CYCLIC AMP | DUKE UNIVERSITY (US) | 2014-05-08 | — | — | US | disclosed |
| US-8114590-B2 | Diagnosis and treatment of chronic lymphocytic leukemia (CLL) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-02-14 | — | — | US | disclosed |
| US-20110224128-A1 | METHODS AND COMPOSITIONS FOR TREATMENT OF MUSCULAR DYSTROPHY | WHALEN ANNE | 2011-09-15 | — | — | US | disclosed |
| US-20110171195-A1 | METHODS AND COMPOSITIONS FOR TREATING URINARY TRACT INFECTIONS USING AGENTS THAT MIMIC OR ELEVATE CYCLIC AMP | DUKE UNIVERSITY (US) | 2011-07-14 | — | — | US | disclosed |
| US-20110117562-A1 | Diagnosis and Treatment of Chronic Lymphocytic Leukemia (CLL) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-05-19 | — | — | US | disclosed |
| US-7846664-B2 | Diagnosis and treatment of chronic lymphocytic leukemia (CLL) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-12-07 | — | — | US | disclosed |
| US-20090239884-A1 | Methods of Treating Inflammation | THE UNIVERSITY OF CONNECTICUT | 2009-09-24 | — | — | US | disclosed |
| US-20090131353-A1 | Diagnosis and Treatment of Chronic Lymphocytic Leukemia (CLL) | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2009-05-21 | — | — | US | disclosed |
| US-20090105281-A1 | Methods of treating inflammation | UNIVERSITY OF CONNECTICUT, THE | 2009-04-23 | — | — | US | disclosed |
| WO-2008113881-A1 | COMPOUND THAT IS A DUAL INHIBITOR OF ENZYMES PDE7 AND/OR PDE4, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS (ES) | 2008-09-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090239884-A1 | Methods of Treating Inflammation | TNF, IL6, IL4 | ALDH1A1 2114/4885TDP1 3851/4885TSHR 4645/4885 |
| US-20110171195-A1 | METHODS AND COMPOSITIONS FOR TREATING URINARY TRACT INFECTIONS USING AGENTS THAT MIMIC OR ELEVATE CYCLIC AMP | PDE7A, PDE8A, PDE8B | ALDH1A1 1738/4885TDP1 2437/4885TSHR 4054/4885 |
| US-20110224128-A1 | METHODS AND COMPOSITIONS FOR TREATMENT OF MUSCULAR DYSTROPHY | PYGM, TNNC1, MYOF | ALDH1A1 3179/4885TDP1 264/4885TSHR 4815/4885 |
| US-20090105281-A1 | Methods of treating inflammation | TNF, IL6, IL4 | ALDH1A1 2114/4885TDP1 3851/4885TSHR 4645/4885 |
| US-20140128399-A1 | METHODS AND COMPOSITIONS FOR TREATING URINARY TRACT INFECTIONS USING AGENTS THAT MIMIC OR ELEVATE CYCLIC AMP | PDE7A, PDE8A, PDE8B | ALDH1A1 1738/4885TDP1 2437/4885TSHR 4054/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.