SCHEMBL18333

SCHEMBL18333

N#Cc1nccc(-c2ccccc2C(F)(F)F)n1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CTSK P43235 4/20 0.56
KMO O15229 3/20 0.56
CTSS P25774 5/20 0.47
CYP1A2 P05177 6/20 0.47
CYP3A4 P08684 5/20 0.47
HSD17B10 Q99714 3/20 0.47
ALOX15 P16050 2/20 0.47
TSHR P16473 2/20 0.47
MAPK1 P28482 1/20 0.47
HIF1A Q16665 1/20 0.47
TDP1 Q9NUW8 1/20 0.47
CYP2C19 P33261 4/20 0.43
ALDH1A1 P00352 3/20 0.43
AR P10275 1/20 0.43
TRPA1 O75762 1/20 0.41
ACP1 P24666 1/20 0.41
IRAK4 Q9NWZ3 1/20 0.41
CYP2D6 P10635 3/20 0.40
USP2 O75604 1/20 0.40
CYP2C9 P11712 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5918444 0.81 TRPV1 (0.48) CTSKKMOCTSSIRAK4
SCHEMBL27964563 0.79 CYP1A2 (0.69) KMOCYP1A2CYP3A4HSD17B10ALOX15
SCHEMBL3364843 0.76 KMO (0.60) KMOCYP1A2CYP3A4HSD17B10ALOX15
SCHEMBL14484877 0.76 KMO (0.45) CTSKKMOCYP1A2CYP3A4HSD17B10
SCHEMBL935401 0.76 KMO (0.60) KMOCYP1A2CYP3A4HSD17B10ALOX15
SCHEMBL25428915 0.76 KMO (0.60) KMOCYP1A2CYP3A4HSD17B10ALOX15
SCHEMBL18469 0.72 CTSS (0.42) CTSKCTSSAR
SCHEMBL4440664 0.72 CTSK (1.00) CTSKCTSS
SCHEMBL18157 0.72 KMO (0.55) CTSKKMOCTSSIRAK4
SCHEMBL1509690 0.72 KMO (0.58) CTSKKMOCTSSCYP1A2MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012025460-A1 OXADIAZOLINONE DERIVATIVES AND USE THEREOF IN PEST CONTROL BAYER CROPSCIENCE AG (DE) 2012-03-01 WO disclosed