Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 2/20 | 0.55 |
| ▸ | CTSS | P25774 | 7/20 | 0.55 |
| ▸ | CTSK | P43235 | 7/20 | 0.55 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.47 |
| ▸ | KIF11 | P52732 | 2/20 | 0.47 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.42 |
| ▸ | TOP1 | P11387 | 2/20 | 0.41 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.40 |
| ▸ | GABBR1 | Q9UBS5 | 1/20 | 0.40 |
| ▸ | GSR | P00390 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MYC | P01106 | 1/20 | 0.37 |
| ▸ | WDR5 | P61964 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18535 | 0.82 | CTSS (0.63) | KMOCTSSCTSKIRAK4KCNH2 | |
| SCHEMBL28024474 | 0.81 | KMO (0.58) | KMOCTSSCTSKIRAK4 | |
| SCHEMBL22738478 | 0.80 | KMO (0.51) | KMOCTSSCTSKIRAK4KDM4E | |
| SCHEMBL1509690 | 0.78 | KMO (0.58) | KMOCTSSCTSKIRAK4KDM4E | |
| SCHEMBL28267570 | 0.78 | MEN1 (0.54) | KIF11TRPV3TOP1KDM4EMEN1 | |
| SCHEMBL3569976 | 0.76 | CTSK (0.64) | CTSSCTSKKIF11KCNH2KDM4E | |
| SCHEMBL3564110 | 0.75 | CTSK (0.67) | CTSSCTSKKIF11KCNH2 | |
| Trifluoroacetic Acid SCHEMBL27908901 | 0.75 | KMO (0.62) | KMOCTSSCTSKIRAK4KCNH2 | |
| SCHEMBL16538634 | 0.75 | HSP90AA1 (0.59) | KMOKIF11TRPV3TOP1KDM4E | |
| SCHEMBL30885864 | 0.75 | KIF11 (0.47) | KMOKIF11TRPV3TOP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120083474-A1 | HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2012-04-05 | — | — | US | disclosed |
| US-20120083474-A1 | HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2012-04-05 | — | — | US | disclosed |
| WO-2012025460-A1 | OXADIAZOLINONE DERIVATIVES AND USE THEREOF IN PEST CONTROL | BAYER CROPSCIENCE AG (DE) | 2012-03-01 | — | — | WO | disclosed |
| WO-2010141805-A1 | HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120083474-A1 | HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 | TRPA1, TRPV1, TRPV2 | KMO 1781/4885CTSS 1408/4885CTSK 1483/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.