SCHEMBL18346348

SCHEMBL18346348

C=C(c1ccccc1)c1ccc(OC)cc1

nearest known ligand 0.83

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CES2 O00748 2/20 0.64
CES1 P23141 2/20 0.64
CA4 P22748 1/20 0.54
CA1 P00915 1/20 0.54
CA2 P00918 1/20 0.54
MEN1 O00255 1/20 0.53
KMT2A Q03164 1/20 0.53
NPC1 O15118 6/20 0.53
RAB9A P51151 6/20 0.53
MAPT P10636 4/20 0.53
PAX8 Q06710 1/20 0.53
NPSR1 Q6W5P4 1/20 0.53
LTA4H P09960 1/20 0.52
CYP1A2 P05177 1/20 0.50
CYP3A4 P08684 1/20 0.50
CYP2C9 P11712 1/20 0.50
CYP2C19 P33261 1/20 0.50
SMN1; SMN2 Q16637 1/20 0.50
CDK5 Q00535 2/20 0.49
CDK5R1 Q15078 2/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2008961 1.00 CES2 (0.64) CES2CES1CA4CA1CA2
SCHEMBL21220132 1.00 CES2 (0.64) CES2CES1CA4CA1CA2
SCHEMBL3277627 0.91 MAPT (0.59) CES2CES1CA1CA2MAPT
SCHEMBL10685198 0.90 LTA4H (0.69) CES2CES1CA4CA1CA2
SCHEMBL15232917 0.84 PDE4A (0.56) CES2CES1CA1CA2MAPT
SCHEMBL10679674 0.84 PARP10 (0.59) CES2CES1CA1CA2MEN1
SCHEMBL14264170 0.83 ACHE (0.65) CES2CES1CA1CA2NPC1
SCHEMBL10518077 0.82 CES2 (0.69) CES2CES1CA4CA1CA2
SCHEMBL7953 0.82 CES2 (0.69) CES2CES1CA4CA1CA2
SCHEMBL4025301 0.82 MEN1 (0.52) CA1CA2MEN1KMT2AMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2016206615-A1 AIE LUMINOGENS FOR VISUALIZATION AND TREATMENT OF CANCER THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) 2016-12-29 WO disclosed