Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 7/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 4/20 | 0.39 |
| ▸ | SLC1A2 | P43004 | 3/20 | 0.34 |
| ▸ | SLC1A1 | P43005 | 3/20 | 0.34 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.34 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
| ▸ | HRH1 | P35367 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3616152 | 0.94 | CA2 (0.47) | CA2MAPK1CA1SLC1A2SLC1A1 | |
| SCHEMBL4142302 | 0.82 | CA2 (0.63) | CA2MAPK1CA1SLC1A2SLC1A1 | |
| SCHEMBL3014658 | 0.81 | CA2 (0.68) | CA2MAPK1CA1SLC1A2SLC1A1 | |
| Hydrochloric Acid SCHEMBL30807529 | 0.80 | CA2 (0.55) | CA2MAPK1CA1SLC1A2SLC1A1 | |
| SCHEMBL1131871 | 0.77 | CA2 (0.68) | CA2MAPK1CA1SLC1A2SLC1A1 | |
| SCHEMBL3020928 | 0.76 | CHRM1 (0.56) | CA2MAPK1CA1SLC1A2SLC1A1 | |
| SCHEMBL165103 | 0.75 | CA2 (0.44) | CA2MAPK1CA1SLC1A2SLC1A1 | |
| SCHEMBL10902355 | 0.74 | CA2 (0.46) | CA2MAPK1CA1SLC1A2SLC1A1 | |
| SCHEMBL35211562 | 0.73 | ACE2 (0.37) | CA1GPR84FFAR1TSHRALDH1A1 | |
| SCHEMBL28703820 | 0.73 | CA2 (0.47) | CA2MAPK1CA1GRIK1GRIK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111285781-B | Preparation method of cilastatin sodium key intermediate | 鲁南制药集团股份有限公司 | 2022-08-05 | — | — | CN | disclosed |
| CN-111285781-A | Preparation method of cilastatin sodium key intermediate | 鲁南制药集团股份有限公司 | 2020-06-16 | — | — | CN | disclosed |
| US-20120253066-A1 | PROCESS FOR THE PREPARATION OF CILASTATIN SODIUM | ORCHID CHEMICALS & PHARMACEUTICALS LIMITED (IN) | 2012-10-04 | — | — | US | disclosed |
| US-8247606-B2 | Process for the preparation of cilastatin and sodium salt | ORCHID CHEMICALS & PHARMACEUTICALS LIMITED (IN) | 2012-08-21 | — | — | US | disclosed |
| US-20120078009-A1 | PROCESS FOR THE PREPARATION OF CILASTATIN AND SODIUM SALT | ORCHID CHEMICALS & PHARMACEUTICALS LIMITED (IN) | 2012-03-29 | — | — | US | disclosed |
| US-8134026-B2 | Process for the preparation of Cilastatin and sodium salt | ORCHID CHEMICALS & PHARMACEUTICALS LIMITED (IN) | 2012-03-13 | — | — | US | disclosed |
| EP-2402312-A1 | An improved process for the preparation of cilastatin acid | Orchid Chemicals&Pharmaceuticals Limited (IN) | 2012-01-04 | — | — | EP | disclosed |
| WO-2011080648-A1 | AN IMPROVED PROCESS FOR THE PREPARATION OF CILASTATIN SODIUM | ORCHID CHEMICALS AND PHARMACEUTICALS LIMITED (IN) | 2011-07-07 | — | — | WO | disclosed |
| WO-2011061609-A2 | PROCESSES FOR THE PREPARATION OF CILASTATIN | RANBAXY LABORATORIES LIMITED (IN) | 2011-05-26 | — | — | WO | disclosed |
| US-20090143614-A1 | Process for the Preparation of Cilastatin and Sodium Salt | ORCHID CHEMICALS & PHARMACEUTICALS LIMITED ORCHID TOWERS (IN) | 2009-06-04 | — | — | US | disclosed |
| US-4668504-A | Use of substituted propenoates to prevent nephrotoxicity of certain antibiotics | MERCK & CO., INC. (US) | 1987-05-26 | — | — | US | disclosed |
| EP-0072014-B1 | COMBINATION OF 2-SUBSTITUTED PENEMS WITH DIPEPTIDASE INHIBITORS | MERCK & CO. INC. (US) | 1986-12-30 | — | — | EP | disclosed |
| US-4616038-A | BACTERICIDES | MERCK & CO., INC. (US) | 1986-10-07 | — | — | US | disclosed |
| EP-0048025-B1 | ANTIBACTERIAL COMPOSITION OF THIENAMYCIN TYPE COMPOUND AND A DIPEPTIDASE INHIBITOR | MERCK & CO. INC. (US) | 1986-01-15 | — | — | EP | disclosed |
| EP-0161546-A1 | Combination of 2-substituted carbapenems with dipeptidase inhibitors | MERCK & CO. INC. (US) | 1985-11-21 | — | — | EP | disclosed |
| US-4539208-A | Combination of thienamycin-type antibiotics with dipeptidase inhibitors | MERCK & CO., INC. (US) | 1985-09-03 | — | — | US | disclosed |
| EP-0072014-A1 | Combination of 2-substituted penems with dipeptidase inhibitors | MERCK & CO. INC. (US) | 1983-02-16 | — | — | EP | disclosed |
| EP-0048301-A1 | 2-(Cyclopropane-carboxamido)-2-alkenoic acids, their esters and salts, and antibacterial compositions comprising the same and a thienamycin-type compound | MERCK & CO. INC. (US) | 1982-03-31 | — | — | EP | disclosed |
| EP-0048025-A1 | Antibacterial composition of thienamycin type compound and a dipeptidase inhibitor | MERCK & CO. INC. (US) | 1982-03-24 | — | — | EP | disclosed |
| EP-0028778-A1 | Antibacterial compositions comprising a beta-lactam-type compound and a 3-substituted propenoate | MERCK & CO. INC. (US) | 1981-05-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120253066-A1 | PROCESS FOR THE PREPARATION OF CILASTATIN SODIUM | ACSL3, PDE12, ACSL5 | CA2 419/4885MAPK1 1312/4885CA1 2238/4885 |
| US-20120078009-A1 | PROCESS FOR THE PREPARATION OF CILASTATIN AND SODIUM SALT | PCSK9, HMGCR, PCSK7 | CA2 18/4885MAPK1 2146/4885CA1 910/4885 |
| US-20090143614-A1 | Process for the Preparation of Cilastatin and Sodium Salt | PCSK9, PCSK7, HMGCR | CA2 18/4885MAPK1 2140/4885CA1 775/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.