Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | PDE1A | P54750 | 1/20 | 0.36 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.36 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | CALCRL | Q16602 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | CYBB | P04839 | 2/20 | 0.35 |
| ▸ | NOX5 | Q96PH1 | 2/20 | 0.35 |
| ▸ | NOX4 | Q9NPH5 | 2/20 | 0.35 |
| ▸ | NOX1 | Q9Y5S8 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20373279 | 0.84 | PDE1A (0.40) | ALDH1A1KDM4EMEN1KMT2APDE1A | |
| SCHEMBL20373585 | 0.81 | POLB (0.38) | ALDH1A1KDM4EMEN1KMT2APOLB | |
| SCHEMBL18359530 | 0.78 | PDE1A (0.37) | ALDH1A1KDM4EMEN1KMT2APOLB | |
| SCHEMBL18359566 | 0.75 | GRM4 (0.39) | MEN1KMT2APOLBPDE1APDE1B | |
| SCHEMBL20373356 | 0.73 | PLA2G2A (0.39) | ALDH1A1KDM4EMEN1KMT2APOLB | |
| SCHEMBL20373360 | 0.72 | MET (0.40) | ALDH1A1KDM4EMEN1KMT2APOLB | |
| SCHEMBL20373449 | 0.71 | SYK (0.38) | PDE1APDE1BPDE1CNOX4PLA2G2A | |
| SCHEMBL20373579 | 0.71 | AR (0.37) | ALDH1A1KDM4EMEN1KMT2APDE1A | |
| SCHEMBL20373445 | 0.70 | TLR7 (0.33) | ALDH1A1KDM4EMEN1KMT2APDE1A | |
| SCHEMBL20373452 | 0.70 | KCNA5 (0.40) | KMT2APDE1APDE1BPDE1CCNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017001733-A1 | BICYCLIC HETEROCYCLE DERIVATIVES AS BROMODOMAIN INHIBITORS | ORION CORPORATION (FI) | 2017-01-05 | — | — | WO | disclosed |